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Malignant Hyperthermia
Aka: Malignant Hyperthermia
- See Also
- Serotonin Syndrome
- Neuroleptic Malignant Sydnrome
- Definition
- Rare, inhalational Anesthetic related rapid rise in Body Temperature, Muscle rigidity, Hypertension and Tachypnea
- Epidemiology
- Rare general Anesthesia complication
- Autosomal Dominant inherited defect
- Causes
- Similar to Neuroleptic Malignant Syndrome (due to Antipsychotics)
- Anesthetic agents in combination with genetic predisposition
- Inhalational Anesthetics
- Succinylcholine
- Pathophysiology
- Ryanodine receptor gene (RYR1) defect effects the Calcium release channel in Muscle
- Results in an unregulated increase in skeletal Muscle oxidative metabolism
- Signs
- Hyperthermia
- Muscle Rigidity
- Hypertension
- Tachypnea
- Lab: Abnormalities
- Metabolic Acidosis
- Respiratory Acidosis
- Creatinine Phosphokinase (CPK) increased (Rhabdomyolysis)
- Serum Creatinine increased
- Complications
- Disseminated Intravascular Coagulation (DIC)
- Respiratory Failure
- Renal Failure
- Cardiovascular Collapse
- Rhabdomyolysis
- Management
- Dantrolene (specific treatment of choice)
- Adult: 1 to 3 mg/kg IV
- Child: 0.5 to 1 mg/kg IV
- Supportive measures (especially until Dantrolene available)
- Benzodiazepines
- Cooling
- References
- (2016) CALS, 14th Ed, 1:126