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Azathioprine
Aka: Azathioprine, Imuran- See Also
- Indications
- Renal homograft maintenance
- Myasthenia Gravis
- Systemic Lupus Erythematosus (Lupus Nephritis)
- Acute Glomerulonephritis
- Pharmacology
- Imidazolyl derivative of mercaptopurine
- Metabolized to mercaptopurine as active ingredient
- Structural Analogue Chemotherapy (purine)
- Imidazolyl derivative of mercaptopurine
- Adverse Effects (similar to mercaptopurine)
- Bone Marrow suppression
- Skin rash
- Drug Fever
- Nausea, Vomiting or Diarrhea
- Hepatic dysfunction (cholestasis, hepatitis)
-
Drug Interactions
- See Cytochrome P-450 3A4
- See Purine Synthesis Inhibitor
- Allopurinol may increase Azathioprine to toxic levels
- Monitoring
Medication Costs | ||
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azathioprine (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
AZATHIOPRINE 50 MG TABLET | Generic | $0.38 each |
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. |
Azathioprine (C0004482) |
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Definition (CHV) | an immunosuppressive drug |
Definition (CHV) | an immunosuppressive drug |
Definition (CHV) | an immunosuppressive drug |
Definition (CHV) | an immunosuppressive drug |
Definition (NCI) | A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. |
Definition (MSH) | An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed) |
Definition (CSP) | immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis; possible carcinogen. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D001379 |
SnomedCT | 391800005, 327060009, 317390007, 111165009, 372574004 |
LNC | LP18898-4, MTHU006794 |
English | Azathioprine, Azothioprine, 1H-Purine, 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-, Azathioprine [gastrointestinal], Azathioprine [gi], Azathioprine [immunosuppress], 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine, azathioprine, Azathioprine [immunosuppressant], AZTP, azathioprine (medication), AZATHIOPRINE, Azathioprine [Chemical/Ingredient], atps, ATP, azothioprine, azaTHIOprine, AzaTHIOprine, Azathioprine - chemical (substance), Azathioprine [immunosuppressant] (product), Azathioprine - chemical, Azathioprine [gastrointestinal] (product), AZT - Azathioprine, Azathioprine (product), Azathioprine (substance), Azathioprine [gastrointestinal] (substance), AZA |
Swedish | Azatioprin |
Czech | azathioprin |
Finnish | Atsatiopriini |
Italian | Azotioprina, Azatioprina |
Russian | IMURAN, AZATIOPRIN, АЗАТИОПРИН, ИМУРАН |
Japanese | イムラン, アザチオプリン |
Polish | Azatiopryna |
Spanish | azatioprina (gastrointestinal) (producto), azatioprina (gastrointestinal), azatioprina (producto), azatioprina (sustancia), azatioprina, Azatioprina |
French | Azathioprine |
German | Azathioprin |
Portuguese | Azatioprina |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Imuran (C0699279) |
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Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D001379 |
English | Immuran, imuran, immuran, Imuran |
French | Imuran |
German | Imuran, Immuran |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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