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Azathioprine

Aka: Azathioprine, Imuran
  1. See Also
    1. Purine Synthesis Inhibitor
  2. Indications
    1. Renal homograft maintenance
    2. Myasthenia Gravis
    3. Systemic Lupus Erythematosus (Lupus Nephritis)
    4. Acute Glomerulonephritis
  3. Pharmacology
    1. Imidazolyl derivative of mercaptopurine
      1. Metabolized to mercaptopurine as active ingredient
    2. Structural Analogue Chemotherapy (purine)
  4. Adverse Effects (similar to mercaptopurine)
    1. Bone Marrow suppression
      1. Leukopenia
      2. Anemia
      3. Thrombocytopenia
    2. Skin rash
    3. Drug Fever
    4. Nausea, Vomiting or Diarrhea
    5. Hepatic dysfunction (cholestasis, hepatitis)
  5. Drug Interactions
    1. See Cytochrome P-450 3A4
    2. See Purine Synthesis Inhibitor
    3. Allopurinol may increase Azathioprine to toxic levels
  6. Monitoring
    1. Complete Blood Count
    2. Liver Function Tests
Medication Costs
azathioprine (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
AZATHIOPRINE 50 MG TABLET Generic $0.38 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Azathioprine (C0004482)

Definition (CHV) an immunosuppressive drug
Definition (CHV) an immunosuppressive drug
Definition (CHV) an immunosuppressive drug
Definition (CHV) an immunosuppressive drug
Definition (NCI) A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.
Definition (MSH) An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
Definition (CSP) immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis; possible carcinogen.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D001379
SnomedCT 391800005, 327060009, 317390007, 111165009, 372574004
LNC LP18898-4, MTHU006794
English Azathioprine, Azothioprine, 1H-Purine, 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-, Azathioprine [gastrointestinal], Azathioprine [gi], Azathioprine [immunosuppress], 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine, azathioprine, Azathioprine [immunosuppressant], AZTP, azathioprine (medication), AZATHIOPRINE, Azathioprine [Chemical/Ingredient], atps, ATP, azothioprine, azaTHIOprine, AzaTHIOprine, Azathioprine - chemical (substance), Azathioprine [immunosuppressant] (product), Azathioprine - chemical, Azathioprine [gastrointestinal] (product), AZT - Azathioprine, Azathioprine (product), Azathioprine (substance), Azathioprine [gastrointestinal] (substance), AZA
Swedish Azatioprin
Czech azathioprin
Finnish Atsatiopriini
Italian Azotioprina, Azatioprina
Russian IMURAN, AZATIOPRIN, АЗАТИОПРИН, ИМУРАН
Japanese イムラン, アザチオプリン
Polish Azatiopryna
Spanish azatioprina (gastrointestinal) (producto), azatioprina (gastrointestinal), azatioprina (producto), azatioprina (sustancia), azatioprina, Azatioprina
French Azathioprine
German Azathioprin
Portuguese Azatioprina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Imuran (C0699279)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D001379
English Immuran, imuran, immuran, Imuran
French Imuran
German Imuran, Immuran
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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