Surgery Book

Bowel Disorders

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Appendicitis

Aka: Appendicitis, Acute appendicitis
  1. Epidemiology
    1. U.S. Appendectomy rates: 300,000 per year (10% are normal appendixes)
    2. Lifetime Incidence
      1. Women: 6.7%
      2. Men: 8.6%
    3. Incidence Pregnancy
      1. Antepartum: 6.3 per 10,000 pregnancies
      2. Postpartum: 9.9 per 10,000 postpartum patients
  2. Pathophysiology
    1. Appendix is long, thin diverticulum
      1. Arises from inferior cecum
    2. Appendicitis course
      1. Luminal obstruction
      2. Increased mucous production
      3. Mucosal Ulceration
      4. Bacterial Infection and overgrowth
      5. Increased wall tension, followed by necrosis and perforation
    3. Appendix Perforation
      1. Perforation Course
        1. Pus spills into peritoneal cavity
        2. Results in peritonitis
        3. Abscess forms
      2. Perforation at time of surgery increases with age
        1. Young patients: 20%
        2. Elderly: 70%
  3. Risk Factors
    1. Decreased Dietary Fiber (high Dietary Fiber protective)
    2. Ingestion of refined carbohydrates
    3. Infection
      1. Viral epidemic
      2. Amebiasis outbreak
      3. Bacterial Gastroenteritis
  4. Precautions
    1. Extremes of age yield atypical presentations
      1. McBurney's Point pain occurs in only 33% of children
      2. Newborns may present only irritable or lethargic, and diagnosis is often delayed until after rupture (80%)
      3. Elderly often have atypical findings and delayed diagnosis
    2. Observe carefully men with Abdominal Pain
      1. Consider referred pain from Scrotum
    3. Initial missed diagnosis approaches 50% (especially at extremes of age)
      1. Often complicated by appendix perforation
    4. Observation protocol in a stable patient when diagnosis is unclear
      1. Outpatient with return for recheck in 12 hours for responsible patients (and parents of pediatric patients)
      2. Hospital observation is recommended when follow-up cannot be assured
      3. Perforation is rare (2%) in first 36 hours of symptoms, and serial exams over this time is reasonable
    5. Imaging
      1. Ultrasound lean pediatric patients first if sonographers and radiologists are experienced with Appendix Ultrasound
      2. CT Abdomen should be obtained if indicated and other modalities are non-diagnostic (despite radiation risk)
        1. Risk of missed appendix outweighs risk of radiation exposure when clinical suspicion dictates
      3. Consider MRI Abdomen in children and pregnant patients
    6. Documentation
      1. Clearly document history, examination, patient stability and decision making
        1. Explain abnormal findings (including labs)
      2. More likely alternative diagnoses should be explained and fit classic diagnostic criteria
        1. Gastroenteritis should primarily be Vomiting and Diarrhea without focal tenderness
        2. Exercise caution in diagnosing Constipation as cause of focal Abdominal Pain
      3. Discharge Instructions should reflect an unclear diagnosis (as opposed to Constipation)
        1. Include precautions for return
        2. Encourage re-evaluation within 24-36 hours if symptoms persist
    7. References
      1. Claudius and Kassinove in Herbert (2012) EM:RAP 12(10): 2-3
      2. Weinstock in Herbert (2018) EM:Rap 18(7): 5-7
  5. Symptoms
    1. Anorexia (low predictive value)
      1. Positive Likelihood Ratio: 1.3 (adults and children)
      2. Negative Likelihood Ratio: 0.64 (LR- 0.58 in children)
      3. Test Sensitivity: 84%
      4. Test Specificity: 66%
    2. Nausea
      1. Positive Likelihood Ratio: 0.69 to 1.2
      2. Negative Likelihood Ratio: 0.7 to 0.84
      3. Test Sensitivity: 58-68%
      4. Test Specificity: 40%
    3. Vomiting
      1. Positive Likelihood Ratio: 0.92 (LR+ 1.3 children)
      2. Negative Likelihood Ratio: 1.1 (LR- 0.65 in children)
      3. Test Sensitivity: 50%
      4. Test Specificity: 45-69%
    4. Abdominal Pain (occurs in virtually all cases)
      1. Predictive value of findings
        1. Right lower quadrant pain (Most important history finding)
          1. Positive Likelihood Ratio: 7.3 to 8.5 (LR+ 1.4 in children)
          2. Negative Likelihood Ratio: <0.28
          3. Test Sensitivity: 81-96%
          4. Test Specificity: 53%
        2. Pain occurs before Vomiting
          1. Positive Likelihood Ratio: 2.8
          2. Test Sensitivity: 100%
          3. Test Specificity: 64%
        3. Pain migration from Periumbilical Pain to Right Lower Quadrant Abdominal Pain
          1. Likelihood Ratio: 3.2 to 3.6 (LR+ 1.8 in children)
          2. Negative Likelihood Ratio: 0.50 (LR- 0.7 in children)
      2. Course of pain (Classic): Occurs in 50% of cases
        1. Initial: Crampy Periumbilical Pain for 12-24 hours
        2. Later: Steady, sharp RLQ Abdominal Pain
        3. Provocative: Cough or Movement
  6. Signs
    1. Typical Presentation
      1. Low grade fever (38.3 - 39.4 C)
        1. Positive Likelihood Ratio: 1.9 (LR+1.2 in children)
        2. Negative Likelihood Ratio: 0.58 (LR- 0.9 in children)
        3. Test Sensitivity: 67%
        4. Test Specificity: 69%
        5. Often absent in elderly
      2. Abdominal rigidity
        1. Positive Likelihood Ratio: 3.8
        2. Negative Likelihood Ratio: 0.82
      3. Involuntary abdominal guarding
        1. Positive Likelihood Ratio: 1.8 (LR+ 2.1 in children)
        2. Negative Likelihood Ratio: <0.54 (LR- 0.47 in children)
        3. Test Sensitivity: 21-74%
        4. Test Specificity: 57-84%
      4. Rebound Abdominal Tenderness (RLQ Abdominal Pain when LLQ pressure is released)
        1. Positive Likelihood Ratio: 2.03 to 6.3 (LR+ 2.2 in children)
        2. Negative Likelihood Ratio: <0.86
        3. Test Sensitivity: 26-63%
        4. Test Specificity: 69%
      5. Point tenderness in right lower quadrant (RLQ)
        1. See McBurney's Point
      6. RLQ tenderness on pelvic exam or rectal exam
      7. Decreased or absent bowel sounds
        1. Positive Likelihood Ratio (children): 3.1
        2. Negative Likelihood Ratio (children): 0.69
    2. Perforated Appendix
      1. Accentuated pain
      2. Vomiting
      3. Higher fever and Leukocytosis
      4. Tender RLQ mass
        1. Suggests Appendiceal abscess
        2. Also seen with Phlegmon (Cecum inflammation)
    3. Extrapelvic Appendix
      1. Right back muscle inflammed (tender below 12th rib)
      2. Psoas and Illiopsoas inflammation
        1. Patient keeps right thigh flexed or rigid extension
        2. Iliopsoas Test (Psoas Sign)
          1. Positive Likelihood Ratio: 2.4 (LR+ 3.2 in children)
          2. Negative Likelihood Ratio: 0.90 (LR- 0.7 in children)
          3. Test Sensitivity: 16%
          4. Test Specificity: 95%
      3. Right Ureter Inflammation (Dysuria or Pyuria)
    4. Intrapelvic Appendix
      1. Diffuse Suprapubic Pain
      2. No abdominal muscle rigidity
      3. Bladder irritation (Dysuria)
      4. Rectum irritation (tenesmus)
      5. Obturator internus inflammation
        1. Obturator Test
      6. Palpable tender mass on rectal exam
    5. Additional exam signs
      1. Rovsing's Sign
        1. Right Lower Quadrant Abdominal Pain occurs on palpation of the left lower quadrant
        2. Positive Likelihood Ratio (children): 3.5
        3. Negative Likelihood Ratio (children): 0.72
      2. Psoas Sign (see above)
        1. Patient in the left lateral decubitus position
        2. Right lower quadrant pain with hyperextension of the the right hip
      3. Obturator Sign (Obturator Test)
        1. Right lower quadrant pain on internal rotation of the flexed right thigh
        2. Positive Likelihood Ratio (children): 3.5
        3. Negative Likelihood Ratio (children): 0.73
      4. Dunphy's Sign
        1. Increased pain with cough
      5. Pain provoked by hopping, percussion or coughing
        1. Positive Likelihood Ratio (children): 1.6
        2. Negative Likelihood Ratio (children): 0.52
  7. Labs
    1. Precautions
      1. No lab marker has sufficient Test Sensitivity to exclude Appendicitis
      2. Al-Abed (2014) Am J Surg S0002-9610(14): 00360-2 [PubMed]
    2. Complete Blood Count: Neutrophilic Leukocytosis
      1. Poor predictive value (poor sensitivity and Specificity)
        1. Leukocytes normal in 20-25% of Appendicitis cases
      2. High Negative Predictive Value
        1. In children, Likelihood Ratio with WBC <10,000 is 0.22
      3. Interpretation
        1. Leukocytes range: 10,000 to 20,000 (in 75% of Appendicitis cases)
        2. Leukocytosis over 15,000 compels evaluation
        3. Higher Leukocytosis suggests appendix perforation
    3. C-Reactive Protein (C-RP)
      1. Increases within 6-12 hours
      2. Test Sensitivity for Appendicitis: 76%
        1. Test Sensitivity improves if C-RP remains normal despite >24 hours of symptoms
        2. In some studies, normal C-RP at 24 hours had a nearly 100% Negative Predictive Value
    4. Urinalysis
      1. Sterile pyuria can occur if appendix is adjacent to ureter
      2. Do not exclude Appendicitis based on urine alone unless urine findings are definitive
  8. Differential Diagnosis
    1. See Abdominal Pain
    2. See Abdominal Pain Causes
    3. See Right Lower Quadrant Abdominal Pain
    4. See Periumbilical Abdominal Pain
    5. Regional ileitis (Crohn's Disease)
    6. Perforated Duodenal Ulcer
    7. Meckel's Diverticulitis
    8. Pelvic Inflammatory Disease
  9. Diagnosis
    1. Alvarado Score (MANTRELS Score)
      1. Unreliable - not recommended (misses almost a third of Appendicitis cases)
    2. Pediatric Appendicitis Score
      1. Unreliable alone, but better efficacy when combined with Appendix Ultrasound (see Pediatric Appendicitis Pathway)
    3. Appendicitis Inflammatory Response Score
    4. No further testing if Appendicitis diagnosis is clear
      1. Based on history and examination
    5. Most suggestive findings of Appendicitis
      1. Adults
        1. Right Lower Quadrant Abdominal Pain
        2. Abdominal rigidity
        3. Radiation of Periumbilical Pain to right lower quadrant
      2. Children
        1. Absent or decreased bowel sounds
        2. Positive Psoas Sign
        3. Positive Obturator Sign
        4. Positive rovsing sign
  10. Imaging
    1. CT Abdomen with contrast
      1. Preferred in most cases (except children and pregnancy)
      2. See CT Abdomen in Appendicitis
    2. RLQ Abdominal Ultrasound
      1. See Ultrasound in Appendicitis
      2. Preferred in children and pregnancy
      3. Combine with pelvic Ultrasound in female patients (consider Ovarian Torsion evaluation)
      4. If appendix is not visualized, or high clinical suspicion despite negative Ultrasound
        1. Appendicitis probability 4.2% if Non-diagnostic Ultrasound and WBC <9k, <65% PMN
          1. Anandalawar (2015) J Am Coll Surg 220(6): 1010-7 [PubMed]
        2. Perform other imaging or perform close interval serial examinations
        3. In children or pregnancy, consider MRI Abdomen
      5. RLQ Abdominal Ultrasound before Abdominal MRI in children is preferred
        1. Ultrasound first strategy is faster and more cost-effective
        2. Despite RLQ Abdominal Ultrasound being inconclusive in 25% of cases
        3. Imler (2017) Acad Emerg Med 24(5): 569-77 +PMID:28207968 [PubMed]
    3. MRI Abdomen (consider in children, pregnancy)
      1. Eliminates the ionizing radiation risk of CT Abdomen
      2. However, longer study (10 min) and may require sedation in children
      3. Test Sensitivity and Test Specificity: 97-100% each
      4. Kearl (2016) Acad Emerg Med 23(2): 179-85 [PubMed]
  11. Management: Surgical Management
    1. Acute Suppurative Appendicitis
      1. Appendectomy
        1. Laparoscopic appendectomy is preferred over open appendectomy
          1. Lower postoperative complications (e.g. Wound Infection), recovery time
          2. Dai (2017) Gastroenterol J 5(4): 542-53 [PubMed]
      2. Antibiotic options prior to surgery (continued if perforation found at surgery)
        1. Metronidazole 500 mg IV q8 hours AND choose one of following
          1. Ceftriaxone 75 mg/kg IV up to 2 g IV q24 hours OR
          2. Ciprofloxacin 400 mg IV q12 hours OR
          3. Levofloxacin 750 mg IV q24 hours
        2. Carbapenem single agent management (choose one)
          1. Moxifloxacin 400 mg IV q24 hours OR
          2. Imipenem 500-1000 mg IV q6 hours OR
          3. Doripenem 500 mg IV q8 hours
      3. Avoid antibiotics with growing resistance to gram-negative Anaerobes
        1. Cefotetan or Cefoxitin
        2. Ampicillin-sulbactam (Unasyn) and Clindamycin
    2. Appendicitis with Abscess
      1. Initial antibiotics as in perforated Appendicitis
        1. Continue antibiotics until no fever or Leukocytosis
      2. Percutaneous drainage
        1. Drain left in place
        2. Remove drain when cathetergram normal
      3. Appendectomy follows drainage
    3. Perforated Appendicitis (esp. with peritonitis or Septic Shock)
      1. Initial antibiotics
        1. Piperacillin-Tazobactam (Zosyn) 3.375 to 4.5 g IV q6-8 hours
        2. Carbapenem single agent management (choose one)
          1. Moxifloxacin 400 mg IV q24 hours OR
          2. Imipenem 500-1000 mg IV q6 hours OR
          3. Doripenem 500 mg IV q8 hours
        3. Metronidazole 500 mg IV q8 hours AND choose one of following
          1. Ciprofloxacin 400 mg IV q12 hours OR
          2. Ceftolozone-Tazobactam 1.5 g IV q8 hours OR
          3. Ceftazidime-Avibactam 2.5 g IV q8 hours OR
          4. Aztreonam 1 g IV q8 hours
          5. Ampicillin 2 g IV q6 hours AND Aminoglycoside (Gentamycin OR Tobramycin)
      2. Appendectomy and perforated or gangrenous appendix
        1. Appendectomy wound left open
        2. Continue antibiotics for 7 days
        3. If fever, Leukocytosis, or obstipation persist
          1. Obtain CT Abdomen and Pelvis
          2. Abscess present
            1. Percutaneous drainage
            2. Base antibiotics on Gram Stain and culture
          3. No abscess
            1. Consider imipenem 500 mg IV q6 hours
    4. References
      1. (2018) Sanford Guide (accessed 7/1/2018)
      2. Helmer (2002) Am J Surg 183:609 [PubMed]
  12. Management: Other Regimens
    1. Appendicitis in Pregnancy (1 case per 1500 births)
      1. Site of surgical incision is controversial
      2. Transverse incision at McBurney's Point recommended
      3. Popkin (2002) Am J Surg 183:20-2 [PubMed]
    2. Antibiotic only treatment
      1. Contraindicated if appendicolith, perforation or abscess
      2. Adult protocol with 73% resolution rate
        1. Ertapenem 15 mg/kg IV bid (children) up to 1 g IV q24 hours (adults) for 2-4 days
        2. Then Levaquin 500 mg daily and Metronidazole 500 mg orally tid for 7 days
        3. Salminen (2015) JAMA 313(23): 2340-8 [PubMed]
      3. Antibiotic options (older, original protocol)
        1. Augmentin for 4 days (original study protocol)
        2. Appendectomy ultimately needed in only 7-12% of cases at 7-30 days and in 12-30% in the next year
        3. Higher risk of peritonitis (8% versus 2%)
          1. However limiting antibiotic only strategy to appendix diameter <10mm might reduce that risk
      4. References
        1. Park (2014) Int J Surg 12(9): 897-900 [PubMed]
        2. Vous (2011) Lancet 377(9777):1573-9 [PubMed]
  13. Prognosis
    1. Mortality overall
      1. Nonperforated: <1%
      2. Perforated: 5%
    2. Mortality if age over 75 years: 25%
  14. References
    1. Claudius in Majoewsky (2012) EM:RAP-C3 2(3): 2
    2. James (1987) Basic Surgical Practice, Hanley, p.218-23
    3. Benabbas (2017) Acad Emerg Med 24(5): 523-51 [PubMed]
    4. Old (2005) Am Fam Physician 71:71-8 [PubMed]
    5. Paulson (2003) N Engl J Med 348:236-42 [PubMed]
    6. Rothrock (2000) Ann Emerg Med 36:39-51 [PubMed]
    7. Snyder (2018) Am Fam Physician 98(1): 25-33 [PubMed]
    8. Wagner (1996) JAMA 276:1589-94 [PubMed]

Appendicitis (C0003615)

Definition (MEDLINEPLUS)

The appendix is a small, tube-like organ attached to the first part of the large intestine. It is located in the lower right part of the abdomen. It has no known function. A blockage inside of the appendix causes appendicitis. The blockage leads to increased pressure, problems with blood flow, and inflammation. If the blockage is not treated, the appendix can burst and spread infection into the abdomen. This causes a condition called peritonitis.

The main symptom is pain in the abdomen, often on the right side. It is usually sudden and gets worse over time. Other symptoms may include

  • Swelling in the abdomen
  • Loss of appetite
  • Nausea and vomiting
  • Constipation or diarrhea
  • Inability to pass gas
  • Low fever

Not everyone with appendicitis has all these symptoms.

Appendicitis is a medical emergency. Treatment almost always involves removing the appendix. Anyone can get appendicitis, but it is more common among people 10 and 30 years old.

National Institute of Diabetes and Digestive and Kidney Diseases

Definition (MSHCZE) Zánět červovitého přívěsku (appendixu), zánět „slepého střeva“. Nejčastější zánětlivá náhlá příhoda břišní. Akutní a. se projevuje celkovou nevolností a bolestí břicha. Ta je v typických případech nejprve neurčitá kolem pupku, později se stěhuje do pravého podbřišku a stává se ostrou a bodavou. Dochází k dráždění pobřišnice a při proděravění appendixu k jejímu zánětu (peritonitidě) s celkově těžkým stavem. U malých dětí, těhotných a u netypicky uloženého appendixu může být průběh odlišný. U žen je někdy třeba odlišit zánět vaječníků (adnexitidu), který může drážděním z appendixu i vznikat. Akutní a. se nejčastěji léčí operativním odstraněním červovitého přívěsku – appendektomií, některé případy se řeší nejprve konzervativně (ledové obklady, dieta, popř. antibiotika). Chronická a. probíhá méně bouřlivě s opakovanými bolestmi břicha. Příznaky nejsou zcela typické, proto je někdy nutné vyloučit jiná onemocnění. Je-li diagnóza potvrzena, volí se obv. operace. (cit. Velký lékařský slovník online, 2013 http://lekarske.slovniky.cz/ )
Definition (MSH) Acute inflammation of the APPENDIX. Acute appendicitis is classified as simple, gangrenous, or perforated.
Concepts Disease or Syndrome (T047)
MSH D001064
ICD9 541, 540-543.99
ICD10 K37
SnomedCT 196785005, 155733005, 307530000, 155736002, 155729003, 155728006, 74400008
English Appendicitis, unqualified, Unspecified appendicitis, appendicitis (diagnosis), appendicitis, Unqualified appendicitis, Appendicitis NOS, Appendicitis, Appendicitis [Disease/Finding], Appendicitis, unqualified (disorder), Appendicitis NOS (disorder), Appendicitis (disorder), inflammation; appendix, appendix; inflammation, Appendicitis, NOS, APPENDICITIS
French APPENDICITE, Appendicite non précisée, Appendicite, non précisée, Appendicite
Portuguese APENDICITE, Apendicite não qualificada, Apendicite
Dutch appendicitis, niet-gekwalificeerd, niet-gekwalificeerde appendicitis, appendix; ontsteking, ontsteking; appendix, Appendicitis, niet gespecificeerd, appendicitis, Appendicitis
German unqualifizierte Appendizitis, Appendizitis, unqualifiziert, Wurmfortsatzentzündung, Blinddarmentzündung, Nicht naeher bezeichnete Appendizitis, Appendizitis
Italian Appendicite, non precisata, Appendicite non definita, Appendicite
Spanish Apendicitis no calificada, apendicitis, SAI (trastorno), apendicitis, SAI, apendicitis, no calificada, Appendicitis NOS, apendicitis, no calificada (trastorno), apendicitis (trastorno), apendicitis, inflamación aguda del apéndice, Apendicitis
Japanese 性質不明の虫垂炎, セイシツフメイノチュウスイエン, チュウスイエン, 虫垂炎, 虫様突起炎
Swedish Blindtarmsinflammation
Czech appendicitida, zánět slepého střeva, apendicitida, Blíže neurčená apendicitida, Apendicitida, Apendicitida, blíže neurčená
Finnish Umpilisäketulehdus
Russian APPENDITSIT, АППЕНДИЦИТ
Korean 상세불명의 충수염
Croatian APENDICITIS
Polish Zapalenie wyrostka robaczkowego
Hungarian Appendicitis, nem minősített, Nem minősített appendicitis, appendicitis
Norwegian Blindtarmbetennelse, Appendisitt
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Acute appendicitis NOS (disorder) (C0085693)

Definition (NCI_NICHD) Appendicitis is a condition characterized by inflammation of the appendix, a small pouch attached to the beginning of the large intestine.
Definition (NCI_CTCAE) A disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent.
Definition (NCI) Acute inflammation of the vermiform appendix.
Concepts Disease or Syndrome (T047)
ICD9 540
ICD10 K35, K35.9, K35.80
SnomedCT 196784009, 155732000, 85189001
English APPENDICITIS ACUTE, Acute appendicitis, unspecified, Acute appendicitis NOS (disorder), acute appendicitis, acute appendicitis (diagnosis), acute inflamed appendicitis (diagnosis), acute inflamed appendicitis, inflamed acute appendicitis, Unspecified acute appendicitis, Acute appendicitis NOS, Appendicitis;acute, appendicitis acute, Appendicitis, Acute appendicitis, Acute appendicitis (disorder), acute; appendicitis, appendicitis; acute, Acute appendicitis, NOS, Acute Appendicitis, Acute appendicitis; not otherwise specified
Dutch acute appendicitis, acuut; appendicitis, appendicitis; acuut, Acute appendicitis, niet gespecificeerd, Acute appendicitis
French Appendicite aiguë
German akute Appendizitis, Akute Appendizitis, nicht naeher bezeichnet, Akute Appendizitis
Italian Appendicite acuta
Portuguese Apendicite aguda
Spanish Apendicitis aguda, apendicitis aguda, SAI, apendicitis aguda, SAI (trastorno), Acute appendicitis NOS, apendicitis aguda (trastorno), apendicitis aguda
Japanese 急性虫垂炎, キュウセイチュウスイエン
Czech Akutní apendicitida
Korean 상세불명의 급성 충수염, 급성 충수염
Hungarian Acut appendicitis
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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