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Rituximab
Aka: Rituximab- Indications
- Refractory Rheumatoid Arthritis
- Non-Hodgkin's Lymphoma
- ANCA Vasculitis
- Contraindications
- Do not use with live virus Vaccines
- Mechanism
- Monoclonal Antibody to the CD20 Antigen that depletes CD20 positive B Cells
- Dosing
- Rheumatoid Arthritis: 1 gram IV every 2 weeks for 2 doses
- Administered with Methylprednisolone 100 mg
- Non-Hodgkin's Lymphoma or ANCA Vasculitis: 375 mg/m2 IV weekly for 4 doses
- Rheumatoid Arthritis: 1 gram IV every 2 weeks for 2 doses
- Adverse Effects
- Severe infusion reactions (follows first infusion within 30-120 minutes)
- Tumor Lysis Syndrome
- Hepatitis B reactivation
- Renal Insufficiency
- Monitoring
- PPD before initiating therapy
- Complete Blood Count at initiation of therapy and then periodically after