Rheumatology Book

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Cyclobenzaprine

Aka: Cyclobenzaprine, Flexeril
  1. See Also
    1. Antispasmodic Skeletal Muscle Relaxant
  2. Indications
    1. Acute back or Neck Pain interfering with sleep despite Analgesics
  3. Class
    1. Antispasmodic Skeletal Muscle Relaxant
  4. Dosing
    1. Start: 5 mg orally at bedtime (5 mg is as effective as 10 mg and with less sedation)
    2. Maximum: 10 mg orally three times daily (primarily at bedtime for pain interfering with sleep)
  5. Contraindications
    1. Older patients
      1. See Medications to Avoid in Older Adults
    2. Seizure disorder (if concurrently on Tramadol)
    3. Glaucoma
    4. Cardiac arrhythmia
    5. Congestive Heart Failure
    6. Recent Myocardial Infarction
  6. Efficacy
    1. See Antispasmodic Skeletal Muscle Relaxant
  7. Adverse effects
    1. See Antispasmodic Skeletal Muscle Relaxant for precautions
    2. Common: Anticholinergic
      1. Drowsiness
      2. Dry Mouth
      3. Urinary Retention
      4. Increased Intraocular Pressure
    3. Rare
      1. Arrhythmia
      2. Seizure
      3. Myocardial Infarction
  8. References
    1. Borenstein (2003) Clin Ther 25(4): 1056-73 [PubMed]
    2. Browning (2001) Arch Intern Med 161: 1613-20 [PubMed]
    3. Tofferi (2004) Arthritis Rheum 51:9-13 [PubMed]
Medication Costs
Cyclobenzaprine (on 6/18/2017 at Walmart.com)
Cyclobenzaprine 10mg #30 tablets for $4.00 $0.13 each
Cyclobenzaprine 10mg #90 tablets for $10.00 $0.11 each
Cyclobenzaprine 5mg #30 tablets for $4.00 $0.13 each
Cyclobenzaprine 5mg #90 tablets for $10.00 $0.11 each
cyclobenzaprine (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
CYCLOBENZAPRINE 10 MG TABLET Generic $0.02 each
CYCLOBENZAPRINE 5 MG TABLET Generic $0.04 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

cyclobenzaprine (C0056732)

Definition (NCI) A centrally acting skeletal muscle relaxant with antidepressant activity. The exact mechanism of action of cyclobenzaprine has not been fully determined, but this drug seems to primarily act at the brain stem to reduce tonic somatic motor activity, influencing both gamma and alpha motor neurons leading to a reduction in muscle spasms.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C004704
SnomedCT 373779004, 80802008
LNC LP17189-9, MTHU004256
English cyclobenzaprine, N,N-dimethyl-3-(dibenzo(a,d)cycloheptene-4-ylidene)propylamine, cyclobenzaprine [Chemical/Ingredient], CYCLOBENZAPRINE, Cyclobenzaprine, Cyclobenzaprine (product), Cyclobenzaprine (substance)
Spanish ciclobenzaprina (producto), ciclobenzaprina (sustancia), ciclobenzaprina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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