Rheumatology Book


Major Histocompatibility Complex Antigens

Aka: Major Histocompatibility Complex Antigens, Human Leukocyte Antigen B27, HLA-B27
  1. Indications
    1. Extremely limited use in clinical practice
    2. May be indicated if spondylitis strongly suspected
  2. Methods of Testing
    1. Antibody binding to patient's cells
    2. Mixed Lymphocyte responses against specific targets
    3. Hybridization to DNA probes
  3. Efficacy
    1. Test Sensitivity for Spondyloarthropathy: 84%
    2. Test Specificity for Spondyloarthropathy: 96%
  4. Conditions associated with HLA-B27 (with Incidence)
    1. Ankylosing Spondylitis: 95%
    2. Reiter's Syndrome: 80%
    3. Spondylitis with Psoriasis: 70%
    4. Spondylitis with Inflammatory Bowel Disease: 50%
    5. Incidence in general population without disease: 6-8%
  5. References
    1. Gregersen in Ruddy (2001) Kelly's Rheumatology, p. 101
    2. Lane (2002) Am Fam Physician 65(6):1073-80

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