Rheumatology Book


Antiphospholipid Antibody

Aka: Antiphospholipid Antibody, aPL Antibody, Antiphospholipid Antibodies
  1. See Also
    1. Antinuclear Antibody
  2. Mechanism
    1. IgM, IgG, or IgA binding to cell-membrane constituents
  3. Screening
    1. Measured by enzyme-linked immunosorbent assay
  4. Types of Antiphospholipid Antibodies
    1. Anticardiolipin (ACL)
    2. Lupus Anticoagulant
      1. Prolongs Partial Thromboplastin Time (PTT)
      2. Prolongs Russell viper venom time
    3. VDRL false positive
  5. Condition associated with APL elevations (>3 SD)
    1. Antiphospholipid Antibody Syndrome
  6. Indications fo APL testing
    1. Connective Tissue disease with clotting disorder
    2. Recurrent thrombosis without obvious cause
      1. See Hypercoagulability

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