Rheumatology Book


ANA Staining Pattern

Aka: ANA Staining Pattern, ANA Rim Pattern, ANA Homogenous Pattern, ANA Speckled Pattern, ANA Nucleolar Pattern, ANA Diffuse Pattern, ANA Centromere Pattern
  1. Rim Pattern
    1. Systemic Lupus Erythematosus (Most Specific)
  2. Homogenous Pattern
    1. Systemic Lupus Erythematosus (Very specific)
    2. Further evaluation
      1. Anti-dsDNA
      2. Anti-ssDNA
      3. Anti-Smith
  3. Speckled Pattern
    1. Most common, least specific
    2. Disorders
      1. Systemic Lupus Erythematosus
      2. Mixed Connective Tissue Disease
      3. Scleroderma
      4. Sjogren's Syndrome
    3. Further evaluation
      1. Smith Antibody (Anti-Smith)
      2. Ribonucleoprotein Antibody (Anti-RNP)
      3. Scl-70 kD kinetochore (Anti-Topoisomerase I)
      4. Anti-La (Anti-SSB)
  4. Nucleolar Pattern
    1. Disorders
      1. Scleroderma
      2. CREST syndrome
    2. Further evaluation
      1. Scl-70 kD kinetochore (Anti-Topoisomerase I)
      2. PM-1
  5. Diffuse Pattern
    1. Non-specific pattern
  6. Centromere Pattern
    1. Seen in PSS with CREST syndrome
  7. References
    1. Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
    2. Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
    3. Callegari (1995) Postgrad Med, 97(4):65-74 [PubMed]
    4. Lane (2002) Am Fam Physician 65(6):1073-80 [PubMed]

Nuclear Ab pattern.homogeneous (C0807128)

Concepts Laboratory or Test Result (T034)
LNC LP29189-5, MTHU009180
English Nuclear Ab pattern.homogeneous, Nuclear Antibody pattern.homogeneous
Derived from the NIH UMLS (Unified Medical Language System)

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