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Hypermobility Signs
Aka: Hypermobility Signs, Joint Hyperextensibility, Joint Laxity, Hypermobility Syndrome, Hypermobility, Hypermobility Spectrum Disorder
- See Also
- Generalized Joint Hypermobility Diagnosis (Beighton Hypermobility Score, Five Point Hypermobility Questionnaire)
- Marfan Syndrome
- Ehlers-Danlos Syndrome (EDS)
- Epidemiology
- Prevalence Hypermobility Syndrome: 0.13 to 0.19%
- Up to 4-11% children demonstrate Hypermobility
- Up to 3-4% of adults report Hypermobility and widespread pain
- Pathophysiology
- Many different conditions demonstrating Hypermobility
- Involves tendon and Muscle laxity and decreased proprioception
- Disordered connective tissue structure
- History: Indications for Screening
- Joint instability (current or past history)
- Joint Dislocations
- Double Jointedness
- Extra-articular findings
- Skin findings
- Velvet-like skin softness
- Atrophic scars
- Skin hyperextensible
- Striae
- Genitourinary or Gastrointestinal Findings
- Recurrent Hernia
- Pelvic Organ Prolapse
- Rectal Prolapse
- Musculoskeletal findings
- Family History of Ehlers-Danlos Syndrome (EDS)
- Marfan Syndrome body habitus
- Chronic Musculoskeletal Pain
- Signs: Joint Hyperextension
- See Beighton Hypermobility Score
- Thumb hyperextension onto Forearm
- Fingers hyperextend to be parallel to Forearm (Metacarpal hyperextension)
- Elbow hyperextension (<0 degrees)
- Knee hyperextension (<0 degrees)
- Ankle dorsiflexion >45 degrees (normally up to 20 degrees)
- Spine hyperextension
- Forward flexion with knees straight, palms on floor
- Diagnosis
- See Generalized Joint Hypermobility Diagnosis (Beighton Hypermobility Score, Five Point Hypermobility Questionnaire)
- Positive Beighton Hypermobility Score (with or without Five Point Hypermobility Questionnaire)
- Evaluate for Hypermobile Ehlers-Danlos Syndrome (EDS)
- Obtain Echocardiogram
- Consider other Hypermobility Syndromes or EDS types
- Causes: Hypermobility Syndromes
- Marfan Syndrome
- Related conditions include MASS Phenotype (Mitral Valve Prolapse), Beals Syndrome
- Ehlers-Danlos Syndrome (EDS)
- Most commonly Hypermobile Ehlers-Danlos Syndrome (80-90% of cases)
- Hypermobility Spectrum Disorders
- Does not meet criteria for Ehlers-Danlos Syndrome (EDS)
- May be generalized, peripheral (hands or feet) or limited to single joint or body part
- May be asymptomatic
- Includes Benign Hypermobility Syndrome (an old diagnosis that has been deprecated)
- Differential Diagnosis
- Chromosomal Disorders (associated with dysmorphic findings, Hypogonadism)
- Down Syndrome
- Aneuploidy
- Hereditary Cutis Laxa
- Loose, inelastic skin
- Hereditary Myopathy (e.g. Bethlem)
- Hypotonia
- Weakness
- Joint Laxity
- Loeys-Dietz Syndrome
- Aortic aneurysm
- Cleft Palate
- Bifid uvula
- Hypertelorism
- Hypotonia
- Skeletal Dysplasia
- Osteogenesis Imperfecta
- Larsen Syndrome
- Other congenital syndromes
- Fragile X Syndrome
- Complications
- Pes Planus
- Hip dysplasia
- Dislocated Patella
- Resources
- Hypermobility Disorders (Hypermobility Syndromes Associations)
- https://www.hypermobility.org/hypermobility-disorders-an-update-for-clinicians
- References
- Yew (2021) Am Fam Physician 103(8): 481-92 [PubMed]