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Mixed Connective Tissue Disease
Aka: Mixed Connective Tissue Disease, Sharp Syndrome, MCTD Syndrome- Definitions
- Mixed Connective Tissue Disease (MCTD)
- Condition with combined features of Systemic Lupus Erythematosus, Myositis and Scleroderma
- Mixed Connective Tissue Disease (MCTD)
- Findings: Presentation
- Labs
- Screening
- ANA Titer
- Confirmation
- Anti-ribonucleoprotein Antibody (Anti-RNP)
- Test Sensitivity for MCTD: 71-100%
- Test Specificity for MCTD: 84-100%
- Anti-ribonucleoprotein Antibody (Anti-RNP)
- Screening
- References
Mixed Connective Tissue Disease (C0026272) |
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|---|---|
| Definition (MSHCZE) | Jedná se převážně o onemocnění autoimunitní, jehož syndrom se překrývá s klinickými příznaky systémového lupus erythematous (SLE), sklerodermie, polymyositidy a Raynaudova fenoménu. Nemoc se rozpozná serologicky podle zvýšené hladiny titrů protilátek vůči nukleárním protilátkám extrahovatelným z fyziologického roztoku ribonukleázou a také podle deposit v epidermálním vzorku metodou přímé imunofluorescence. R |
| Definition (NCI) | An autoimmune overlap syndrome characterized by the presence of symptoms of systemic lupus erythematosus, systemic scleroderma, and polymyositis. |
| Definition (MSH) | A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence. |
| Concepts | Disease or Syndrome (T047) |
| MSH | D008947 |
| ICD10 | M35.1 |
| SnomedCT | 33110008, 398049005, 398021003 |
| English | Connective Tissue Disease, Mixed, MCTD, Sharp Syndrome, Syndrome, Sharp, Connect tissue dis overlap syn, Mixed conn tissue disease, CONNECTIVE TISSUE DIS MIXED, MIXED CONNECTIVE TISSUE DIS, MCTD-Mixed conn tissue disease, mixed connective tissue disease (diagnosis), mixed connective tissue disease, Mixed Connective Tissue Disease, Mixed Connective Tissue Disease [Disease/Finding], connective tissue disease mixed, mctd, mix connective tissue disease, sharp syndrome, collagen disease mixed vascular, connective disease mixed tissue, connective mixed tissue disease, mixed collagen vascular disease, Mixed connective tissue disease, Mixed collagen vascular disease, Connective tissue disease overlap syndrome, Sharp's syndrome, MCTD - Mixed connective tissue disease, Connective tissue disease overlap syndrome (disorder), Mixed collagen vascular disease (disorder), disease (or disorder); mixed connective tissue, disease (or disorder); mixed, connective tissue, disease; mixed connective tissue, mixed, connective tissue; disorder, Mixed collagen vascular disease, NOS, Mixed connective tissue disease, NOS |
| French | Collag mixte, Connectivite mixte, Syndrome de Sharp |
| German | MCTD, kombinierte Kollagenosen, Connective Tissue Disease, Mixed, Mischkollagenose, Mixed Connective Tissue Disease, Sharp-Syndrom |
| Italian | Patologia mista del tessuto connettivo, Sindrome di Sharp, MCTD, Malattia del tessuto connettivo mista |
| Spanish | EMTC, enfermedad colágeno - vascular mixta, enfermedad colágeno - vascular mixta (trastorno), enfermedad vascular mixta del colágeno (trastorno), enfermedad vascular mixta del colágeno, síndrome de superposición de enfermedades del tejido conectivo, síndrome de superposición de enfermedades del tejido conjuntivo (trastorno), síndrome de superposición de enfermedades del tejido conjuntivo, Enfermedad mixta del tejido conjuntivo, Enfermedad Mixta del Tejido Conectivo, Enfermedad Mixta del Tejido Conjuntivo, Síndrome de Sharp |
| Japanese | ＭＣＴＤ, ｼｬｰﾌﾟｼｮｳｺｳｸﾞﾝ, MCTD, ｺﾝｺﾞｳｾｲｹﾂｺﾞｳｿｼｷﾋﾞｮｳ, 混合性結合組織病, Mixed Connective Tissue病, Sharp症候群, 混合型結合組織病, 混合性結合組織疾患, 混合性結合織疾患, 混合性結合織病, 混合結合組織疾患, 混合結合組織病, 結合組織疾患-混合, シャープ症候群, 結合組織病-混合性 |
| Swedish | Blandad bindvävssjukdom |
| Czech | pojivová tkáň - nemoci smíšené, Smíšené onemocnění pojiva, Sharpův syndrom |
| Finnish | Sekamuotoinen sidekudossairaus |
| Russian | SOEDINITEL'NOI TKANI PORAZHENIE SMESHANNOE, SOEDINITEL'NOI TKANI BOLEZNI SMESHANNYE, SHARPA SINDROM, СОЕДИНИТЕЛЬНОЙ ТКАНИ БОЛЕЗНИ СМЕШАННЫЕ, СОЕДИНИТЕЛЬНОЙ ТКАНИ ПОРАЖЕНИЕ СМЕШАННОЕ, ШАРПА СИНДРОМ |
| Croatian | MJEŠOVITA BOLEST VEZIVNOG TKIVA |
| Polish | Choroba tkanki łącznej mieszana, Kolagenoza mieszana |
| Hungarian | Kevert kötőszöveti betegség, Sharp-syndroma, MCTD |
| Norwegian | Blandet bindevevssykdom, MCTD, Sharps syndrom |
| Dutch | aandoening; gemengd, bindweefsel, aandoening; mixed connective tissue, disease; mixed connective tissue, gemengd, bindweefsel; aandoening, mixed connective tissue disease, Bindweefselziekte, gemengde, Gemengde bindweefselziekte, Sharp-syndroom, Ziekte, gemengde bindweefsel- |
| Portuguese | Doença mista do tecido conjuntivo, Doença Mista do Tecido Conectivo, Doença Mista do Tecido Conjuntivo, Síndrome de Sharp |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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