Rheumatology Book


Osteoporosis Secondary Causes

Aka: Osteoporosis Secondary Causes
  1. See Also
    1. Medication Causes of Osteoporosis
    2. Corticosteroid Associated Osteoporosis
    3. Osteoporosis
    4. Osteoporosis Evaluation
    5. Osteoporosis Management
  2. Causes: Endocrine Causes
    1. Hyperparathyroidism
    2. Grave's Disease or Hyperthyroidism
    3. Cushing's Disease
    4. Hyperprolactinemia (Prolactinoma)
    5. Hypogonadism
      1. Women: Menopause
      2. Men: "Male Menopause"
        1. Declining Testosterone and Estradiol
        2. Orchiectomy in Prostate Cancer
  3. Causes: Nutrition
    1. Vitamin D Deficiency (very common in elderly)
      1. Community-dwelling elderly: 36% men, 47% women
      2. Long-term Care Residents: 80-100% Prevalence
    2. Alcoholism or Alcohol use more than 2 drinks per day
    3. Gastric Bypass Surgery
    4. Malabsorption syndromes (esp. Celiac Sprue)
    5. Malnutrition
    6. Vitamin A Excess
    7. Anorexia Nervosa (and Female Athlete Triad)
    8. Bulimia Nervosa
    9. Calcium deficiency (e.g. Hypercalciuria)
  4. Causes: Miscellaneous Chronic Disease
    1. Chronic Renal Failure
    2. Rheumatoid Arthritis
    3. Systemic Lupus Erythematosus
    4. Chronic Liver Disease
    5. Chronic Obstructive Pulmonary Disease (COPD)
    6. Human Immunodeficiency Virus or AIDS
    7. Mastocytosis
    8. Organ transplant
  5. Causes: Malignancy
    1. Multiple Myeloma
    2. Leukemia
    3. Lymphoma
    4. Ectopic ACTH Syndrome
  6. Causes: Genetic Syndromes
    1. Osteogenesis imperfecta
    2. Marfan Syndrome
    3. Ehlers-Danlos Syndrome
    4. Homocystinuria
    5. Glycogen Storage Diseases
    6. Hypophosphatasia
  7. Causes: Neurologic
    1. Seizure Disorder
    2. Multiple Sclerosis
    3. Parkinonism
    4. Spinal cord injury
    5. Cerebrovascular Accident
  8. Causes: Medications
    1. See Medication Causes of Osteoporosis
    2. See Corticosteroid Associated Osteoporosis
  9. References
    1. Jeremiah (2015) Am Fam Physician 92(4): 261-8 [PubMed]
    2. Mauck (2006) Mayo Clin Proc 81(5):662-72 [PubMed]
    3. Sweet (2009) Am Fam Physician 79(3): 193-202 [PubMed]

Secondary generalized osteoporosis (C0473771)

Concepts Acquired Abnormality (T020)
SnomedCT 240157009
English Second general osteoporosis, Secondary generalised osteoporosis, Secondary generalized osteoporosis, Secondary generalized osteoporosis (disorder)
Spanish osteoporosis generalizada secundaria (trastorno), osteoporosis generalizada secundaria
Derived from the NIH UMLS (Unified Medical Language System)

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