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Medication Causes of Edema
Aka: Medication Causes of Edema, Edema Secondary to Medications
- See Also
- Generalized Edema
- Generalized Edema Below the Diaphragm
- Generalized Edema Above the Diaphragm
- Localized Edema
- Mechanism
- Edema is typically due to salt and water retention unless otherwise noted
- Causes: Antihypertensives
- Hydralazine
- Diazoxide (Hyperstat)
- Minoxidil
- Methyldopa
- Calcium Channel Blockers (e.g. Amlodipine)
- Beta Blockers
- Clonidine (Catapres)
- Causes: Endocrine agents
- Corticosteroids
- Estrogen
- Progesterone
- Testosterone
- Insulin
- Thiazolidinedione (e.g. Actos, Avandia)
- Causes: Neurologic and Psychiatric Medications
- Antidepressants
- Monoamine Oxidase Inhibitors
- Trazodone
- Antipsychotics: Phenothiazines
- Thioridazine (Mellaril)
- Chlorpromazine (Thorazine)
- Trifluoperazine (Stelazine)
- Thiothixene (Navane)
- Neurologic Medications
- Dopamine Agonists such as Pramipexole (Mirapex)
- Gabapentin
- Pregabalin
- Causes: Chemotherapy
- Interleukin-2 (Increased Vascular permeability)
- Interleukin-4
- Interferon alfa
- Docetaxel (Taxotere)
- Cyclophosphamide
- Cyclosporine
- Mithramycin
- Cytosine Arbinoside
- Granulocyte colony-stmulating factor
- Granulocyte-macrophage Colony Stimulating Factor
- Causes: Miscellaneous agents
- Acyclovir (Zovirax)
- Buprenorphine
- Diuretic Abuse or Laxative abuse
- Increases renin and Aldosterone levels
- Rebound salt retention on stopping medication
- Nonsteroidal Antiinflammatory Drugs (NSAIDs)
- Ibuprofen
- Celecoxib (Celebrex)
- References
- (2019) Presc Lett
- Trayes (2013) Am Fam Physician 88(2): 102-10 [PubMed]