Nephrology Book


Transtubular Potassium Gradient

Aka: Transtubular Potassium Gradient
  1. See Also
    1. Potassium Homeostasis
    2. Serum Potassium
    3. Urine Potassium
    4. Hyperkalemia
    5. Hypokalemia
  2. Indications
    1. Hyperkalemia
  3. Precautions
    1. Results altered by Hyperkalemia Management
    2. Obtain lab sample prior to intervention if possible
      1. Do not delay treatment in emergent Hyperkalemia
  4. Labs
    1. Serum Potassium and Serum Osmolality
    2. Spot urine for Urine Potassium and Urine Osmolality
  5. Calculation: Transtubular Potassium Gradient (TTPG)
    1. TTPG = (Urine K++ x Serum Osm)/(Serum K++ x Urine Osm)
    2. Where K+ is Potassium and Osm is Osmolality
  6. Interpretation: Fractional Excretion of Potassium
    1. TTPG <6-8%: Renal cause of Hyperkalemia
      1. Hypoaldeosteronism suggested by very low TTPG
    2. TTPG >6-8: Extrarenal cause of Hyperkalemia
      1. May also be increased in Chronic Renal Failure

Transtubular potassium gradient (C0919835)

Concepts Laboratory Procedure (T059)
Italian Gradiente transtubulare di potassio
Japanese 経尿細管性カリウム勾配, ケイニョウサイカンセイカリウムコウバイ
English Transtubular potassium gradient
Czech Transtubulární draslíkový gradient
Hungarian Transtubularis kálium gradiens
Portuguese Gradiente transtubular de potássio
Spanish Gradiente transtubular de potasio
Dutch transtubulaire kaliumgradiënt
French Gradient trans-tubulaire du potassium
German Transtubulaerer Kaliumgradient
Derived from the NIH UMLS (Unified Medical Language System)

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