Nephrology Book

//fpnotebook.com/

Type 1 Renal Tubular Acidosis

Aka: Type 1 Renal Tubular Acidosis, Type I Renal Tubular Acidosis, Type I RTA, Distal RTA, Distal Renal Tubular Acidosis, Classic RTA
  1. See Also
    1. Renal Tubular Acidosis
  2. Pathophysiology
    1. Distal Tubule fails to excrete ammonium
  3. Causes
    1. Autosomal Dominant inherited disorder
    2. Acquired causes
      1. Systemic Lupus Erythematosus
      2. Sickle Cell Anemia
      3. Nephrocalcinosis related disorders
        1. Hyperparathyroidism
        2. Medullary sponge Kidney
      4. Medications and Toxins
        1. Amphotericin B
        2. Lithium
        3. Toluene
  4. Signs
    1. Musculoskeletal weakness
    2. Recurrent Nephrolithiasis
  5. Labs
    1. Arterial Blood Gas (ABG)
      1. Non-Anion Gap Metabolic Acidosis
    2. Urine pH
      1. Elevated >5.5 despite Metabolic Acidosis
    3. Serum Potassium
      1. Low or normal
    4. Fractional Excretion of Bicarbonate
      1. FE-HCO3 <5%: Distal RTA
      2. FE-HCO3 >15%: Proximal RTA
        1. Assumes serum bicarbonate >20 meq/L
  6. Management: Bicarbonate Supplementation
    1. Dose: 1-2 meq/kg/day
    2. Goal: Serum bicarbonate > 22 meq/L
    3. Corrects Hypokalemia

You are currently viewing the original 'fpnotebook.com\legacy' version of this website. Internet Explorer 8.0 and older will automatically be redirected to this legacy version.

If you are using a modern web browser, you may instead navigate to the newer desktop version of fpnotebook. Another, mobile version is also available which should function on both newer and older web browsers.

Please Contact Me as you run across problems with any of these versions on the website.

Navigation Tree