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Ziprasidone

Aka: Ziprasidone, Geodon
  1. Indications
    1. Schizophrenia (including acute episodic agitation)
    2. Mania
    3. Bipolar Disorder
    4. Tourette's Syndrome (not FDA approved)
  2. Mechanism
    1. Primarily a Serotonin 2A antagonist (Dopamine antagonist activity is much less)
  3. Class
    1. Atypical Antipsychotic (Second Generation agent)
  4. Dosing
    1. Oral
      1. Ziprasidone 20 to 80 mg orally twice daily
    2. Parenteral
      1. Ziprasidone 10 to 20 mg IM
  5. Advantages
    1. Minimal weight gain than with other Atypical Antipsychotics
    2. Lower risk of diabetes than with other Atypical Antipsychotics
  6. Drug Interactions
    1. Increase Antipsychotic levels (toxicity risk): Monitor for toxicity
      1. Clarithromycin
      2. Erythromycin
      3. Grapefruit juice
      4. Fluconazole
      5. Itraconazole
      6. Ketoconazole
    2. Decrease Antipsychotic levels (lower efficacy)
      1. Carbamazepine
      2. Phenytoin
  7. Adverse Effects
    1. Lower Extrapyramidal Side Effects compared with other Antipsychotics
    2. Somnolence (esp. Overdose)
    3. Nausea
    4. Weakness
    5. QTc Prolongation (more than with other Atypical Antipsychotics)
  8. Monitoring
    1. See Antipsychotics
  9. References
    1. Glauser and Peters (2016) Crit Dec Emerg Med 30(4): 17-27
Medication Costs
ziprasidone (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
ZIPRASIDONE HCL 20 MG CAPSULE Generic $0.61 each
ZIPRASIDONE HCL 40 MG CAPSULE Generic $0.59 each
ZIPRASIDONE HCL 60 MG CAPSULE Generic $0.67 each
ZIPRASIDONE HCL 80 MG CAPSULE Generic $0.68 each
geodon (on 6/1/2017 at Medicaid.Gov Pharmacy Drug pricing)
GEODON 20 MG CAPSULE Generic $0.61 each
GEODON 40 MG CAPSULE Generic $0.59 each
GEODON 60 MG CAPSULE Generic $0.67 each
GEODON 80 MG CAPSULE Generic $0.68 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

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