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Ziprasidone
Aka: Ziprasidone, Geodon
- Indications
- Schizophrenia (including acute episodic Agitation)
- Mania
- Bipolar Disorder
- Tourette's Syndrome (not FDA approved)
- Mechanism
- Primarily a Serotonin 2A antagonist (Dopamine antagonist activity is much less)
- Class
- Atypical Antipsychotic (Second Generation agent)
- Dosing
- Oral
- Ziprasidone 20 to 80 mg orally twice daily
- Parenteral
- Ziprasidone 10 to 20 mg IM
- Advantages
- Minimal weight gain than with other Atypical Antipsychotics
- Lower risk of diabetes than with other Atypical Antipsychotics
-
Drug Interactions
- Increase Antipsychotic levels (toxicity risk): Monitor for toxicity
- Clarithromycin
- Erythromycin
- Grapefruit juice
- Fluconazole
- Itraconazole
- Ketoconazole
- Decrease Antipsychotic levels (lower efficacy)
- Carbamazepine
- Phenytoin
- Adverse Effects
- Lower Extrapyramidal Side Effects compared with other Antipsychotics
- Somnolence (esp. Overdose)
- Nausea
- Weakness
- QTc Prolongation (more than with other Atypical Antipsychotics)
- Monitoring
- See Antipsychotics
- References
- Glauser and Peters (2016) Crit Dec Emerg Med 30(4): 17-27