Mental Health Book



Aka: Temazepam, Restoril
  1. See Also
    1. Benzodiazepine
  2. Class
    1. Medium Acting Benzodiazepine
  3. Indications
    1. Insomnia with frequent awakening
  4. Dose
    1. Restoril 7.5 to 30 mg PO 1-2 hours before bedtime
  5. Pharmacokinetics
    1. Onset: 30-60 minutes
    2. Duration: 6-8 hours
    3. Half-Life: 8-12 hours
    4. Serum levels peak in 2-3 hours after oral dose
  6. Background
    1. Weekly Cost: $1-2
    2. Exception: 7.5 mg costs $200/month
  7. Advantages
    1. Less daytime sedation or accumulation
  8. Disadvantages
    1. More risk of rebound Insomnia
  9. Equivalent dosing (for Benzodiazepine Withdrawal)
    1. Valium = Dose x1.0
    2. Phenobarbital = Dose x3.0
Medication Costs
temazepam (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
TEMAZEPAM 15 MG CAPSULE Generic $0.07 each
TEMAZEPAM 22.5 MG CAPSULE Generic $4.57 each
TEMAZEPAM 30 MG CAPSULE Generic $0.08 each
TEMAZEPAM 7.5 MG CAPSULE Generic $3.12 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Temazepam (C0039468)

Definition (NCI) A benzodiazepine derivative with antidepressant, sedative, hypnotic and anticonvulsant properties. Temazepam potentiates the inhibitory activities of gamma-aminobutyric acid (GABA) by binding to the GABA receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreases neuronal excitability.
Definition (MSH) A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D013693
SnomedCT 334023006, 321143008, 387300007, 54705000
LNC LP14551-3, MTHU001573
English 3-Hydroxydiazepam, Hydroxydiazepam, Methyloxazepam, Oxydiazepam, Temazepam, 3 Hydroxydiazepam, 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-, Temazepam [anaesthesia], Temazepam [anesthesia], Temazepam [hypnotic], 10-chloro-4-hydroxy-6-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-2,8,10,12-tetraen-5-one, temazepam, temazepam (medication), TEMAZEPAM, Temazepam [Chemical/Ingredient], Temazepam [anesthesia] (product), Temazepam [hypnotic] (product), Temazepam (product), Temazepam (substance), Temazepam [anesthesia] (substance), Temazepam [hypnotic] (substance)
Swedish Temazepam
Czech temazepam
Finnish Tematsepaami
Japanese テマゼパム, ヒドロキシジアゼパム, メチルオキサゼパム
Polish Temazepam
Spanish temazepam [hipnótico] (producto), temazepam [anestésico] (producto), temazepam [hipnótico], temazepam [anestésico], temacepam (producto), temacepam (sustancia), temacepam, temazepam (sustancia), temazepam, Hidroxidiazepam, Metiloxazepam, Temazepam
French Témazépam
German Hydroxydiazepam, Methyloxazepam, Temazepam, 3-Hydroxydiazepam, Oxydiazepam
Italian Temazepam
Portuguese Hidroxidiazepam, Metiloxazepam, Temazepam
Derived from the NIH UMLS (Unified Medical Language System)

Restoril (C0723045)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D013693
German Restoril
English restoril, Restoril, Mallinckrodt Brand of Temazepam, Novartis Brand of Temazepam
Derived from the NIH UMLS (Unified Medical Language System)

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