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Quazepam

Aka: Quazepam, Doral
  1. See Also
    1. Benzodiazepine
  2. Class
    1. Long acting Benzodiazepine
  3. Indications
    1. Insomnia
  4. Dose
    1. Insomnia
      1. 7.5-30 mg PO qhs
    2. Anxiety
      1. Maximum Daily Dose: 15 mg
  5. Pharmacokinetics
    1. Half-Life: 39 hours
  6. Background
    1. Weekly Cost: $5.08

quazepam (C0072828)

Definition (NCI) A synthetic benzodiazepine derivative with anxiolytic, sedative and hypnotic properties. Quazepam and its major metabolite 2-oxoquazepam potentiate gamma-aminobutyric acid (GABA) activity by binding to the benzodiazepine-1 recognition site (BZ-1) within the GABA-A receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of GABA-activated chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreased neuronal excitability.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C025130
SnomedCT 108391004, 371372004
LNC LP17870-4, MTHU024725
English 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-2H-1,4-benzodiazepine-2-thione, quazepam, 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-, quazepam (medication), quazepam [Chemical/Ingredient], QUAZEPAM, Quazepam (substance), Quazepam product (product), Quazepam product, Quazepam
Spanish quazepam, producto (producto), quazepam (producto), quazepam, quazepam, producto, quazepam (sustancia), cuacepam (sustancia), cuazepam, cuacepam
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Doral (C0720023)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C025130
English Doral, doral, Wallace brand of quazepam
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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