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Quazepam
Aka: Quazepam, Doral- See Also
- Class
- Long acting Benzodiazepine
- Indications
- Dose
- Insomnia
- 7.5-30 mg PO qhs
- Anxiety
- Maximum Daily Dose: 15 mg
- Insomnia
- Pharmacokinetics
- Half-Life: 39 hours
- Background
- Weekly Cost: $5.08
quazepam (C0072828) |
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Definition (NCI) | A synthetic benzodiazepine derivative with anxiolytic, sedative and hypnotic properties. Quazepam and its major metabolite 2-oxoquazepam potentiate gamma-aminobutyric acid (GABA) activity by binding to the benzodiazepine-1 recognition site (BZ-1) within the GABA-A receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of GABA-activated chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreased neuronal excitability. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C025130 |
SnomedCT | 108391004, 371372004 |
LNC | LP17870-4, MTHU024725 |
English | 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-2H-1,4-benzodiazepine-2-thione, quazepam, 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-, quazepam (medication), quazepam [Chemical/Ingredient], QUAZEPAM, Quazepam (substance), Quazepam product (product), Quazepam product, Quazepam |
Spanish | quazepam, producto (producto), quazepam (producto), quazepam, quazepam, producto, quazepam (sustancia), cuacepam (sustancia), cuazepam, cuacepam |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Doral (C0720023) |
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Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
MSH | C025130 |
English | Doral, doral, Wallace brand of quazepam |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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