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Nortriptyline
Aka: Nortriptyline, Aventyl, Pamelor- Background
- Cost: $60 per month
- Dosing: Depression
- Start at 25mg PO qhs for 3 days
- Next: 50 mg PO qhs for 3 days
- Therapeutic Dose: 75 mg PO qhs
- Pharmacokinetics
- Not effective at low dose
- Therapeutic serum level: 50 to 150 ng/ml
- Serum Half Life: 36 hours
- Narrow therapeutic window
- Always obtain a serum level after 75 mg for 7 days
- Adverse effects
- See Tricyclic Antidepressants
- Much less adverse effects than tertiary amines
- Moderate adverse effects
- Sedation
- Cardiac Arrhythmia
- Precautions
- See Tricyclic Antidepressants
- Serious cardiotoxicity in overdosage
- Advantages
- Good nighttime sleep without daytime grogginess
- Inexpensive (generic)
Medication Costs | ||
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Nortriptyline (on 6/18/2017 at Walmart.com) | ||
Nortriptyline 10mg | #30 capsules for $4.00 | $0.13 each |
Nortriptyline 10mg | #90 capsules for $10.00 | $0.11 each |
Nortriptyline 25mg | #30 capsules for $4.00 | $0.13 each |
Nortriptyline 25mg | #90 capsules for $10.00 | $0.11 each |
nortriptyline (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
NORTRIPTYLINE 10 MG/5 ML SOL | Generic | $0.25 per ml |
NORTRIPTYLINE HCL 10 MG CAP | Generic | $0.09 each |
NORTRIPTYLINE HCL 25 MG CAP | Generic | $0.13 each |
NORTRIPTYLINE HCL 50 MG CAP | Generic | $0.17 each |
NORTRIPTYLINE HCL 75 MG CAP | Generic | $0.25 each |
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. |
Nortriptyline (C0028420) |
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Definition (NCI) | A tricyclic antidepressant agent used for short-term treatment of various forms of depression. Nortriptyline blocks the norepinephrine presynaptic receptors, thereby blocking the reuptake of this neurotransmitter and raising the concentration in the synaptic cleft in the CNS. Nortriptyline also binds to alpha-adrenergic, histaminergic and cholinergic receptors. Long-term treatment with nortriptyline produces a downregulation of adrenergic receptors due to the increased stimulation of these receptors. |
Definition (CSP) | tricyclic antidepressant of the dibenzocycloheptadiene class used to treat symptoms of depression and to relieve chronic, severe pain. |
Definition (MSH) | A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D009661 |
SnomedCT | 321855000, 13432000, 372652004 |
LNC | LP14984-6, MTHU005025 |
English | Desitriptyline, Desmethylamitriptylin, Nortriptyline, nortriptyline, 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl-, Nortriptyline [Chemical/Ingredient], nortryptyline, NORTRIPTYLINE, Nortryptyline, Nortriptyline (product), Nortriptyline (substance), NTPL |
Swedish | Nortriptylin |
Czech | nortriptylin |
Finnish | Nortriptyliini |
Russian | NORTRIPTILIN, DESITRIPTILIN, DESMETILAMITRIPTILIN, DEZITRIPTILIN, ДЕСИТРИПТИЛИН, ДЕСМЕТИЛАМИТРИПТИЛИН, НОРТРИПТИЛИН, ДЕЗИТРИПТИЛИН |
Japanese | デシトリプチリン, デスメチルアミトリプチリン, 塩酸ノルトリプチリン, ノルトリプチリン |
Polish | Nortryptylina |
Spanish | nortriptilina (producto), nortriptilina (sustancia), nortriptilina, Nortriptilina, Desitriptilina, Desmetilamitriptilina |
French | Nortriptyline |
German | Desitriptylin, Desmethylamitriptylin, Nortriptylin |
Italian | Nortriptilina |
Portuguese | Desitriptilina, Desmetilamitriptilina, Nortriptilina |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Pamelor (C0030256) |
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Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D009661 |
English | pamelor, Mallinckrodt Brand of Nortriptyline Hydrochloride, Pamelor |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Aventyl (C0528314) |
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Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
MSH | D009661 |
English | aventyl, Allegron, Dista Brand of Nortriptyline Hydrochloride, Lilly Brand of Nortriptyline Hydrochloride, Paxtibi, Aventyl |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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