Mental Health Book


Intranasal Nicotine

Aka: Intranasal Nicotine, Nicotine Nasal Spray, Nicotrol NS
  1. See Also
    1. Tobacco Abuse
    2. Nicotine Replacement
  2. Indications
    1. Tobacco Cessation
  3. Efficacy
    1. One year quit rate 25% (12% for Placebo)
    2. Best in obese heavy smokers and non-white patients
      1. Lerman (2004) Ann Intern Med 140:426-33 [PubMed]
  4. Mechanism
    1. Rapidly absorbed via nasal mucosa
  5. Preparations
    1. Available only by prescription in the United States
    2. Concentration 10 mg/ml and provides 0.5 mg/spray
    3. Each bottle contains 10 ml
  6. Dosing
    1. One dose is 1 spray each nostril (1 mg Nicotine)
    2. Start 1-2 doses per hour while awake for 8 weeks
      1. Do not exceed 5 doses per hour (or more than 40 doses per day)
    3. Taper over the next month
    4. Minimum recommended: 8 doses (8 mg) per day
    5. Maximum: 40 doses (40 mg) per day
    6. Do not use more than 6 months total
  7. Contraindications
    1. Same as Nicotine Patch
    2. Bronchospasm
  8. Adverse Effects
    1. Nasal Irritation (90%): Rhinorrhea or sneezing
      1. Symptoms may be severe
      2. Often continues throughout course of use
    2. Throat irritation
    3. Nausea
    4. Watery eyes
    5. Cough
  9. Precautions
    1. Pregnancy Category D
    2. Greater abuse potential than Nicotine Patch or gum
  10. References
    1. Larzelere (2012) Am Fam Physician 85(6):591-8 [PubMed]
Medication Costs
nicotrol ns (on 6/1/2017 at Medicaid.Gov Pharmacy Drug pricing)
NICOTROL NS 10 MG/ML SPRAY $9.61 per ml
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Nicotrol NS (C0939401)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Nicotrol NS
Derived from the NIH UMLS (Unified Medical Language System)

Nicotine Nasal Inhaler (C1249285)

Concepts Clinical Drug (T200)
English Nicotine Nasal Inhaler
Derived from the NIH UMLS (Unified Medical Language System)

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