Mental Health Book



Aka: Halazepam, Paxipam
  1. See Also
    1. Benzodiazepine
  2. Indication
    1. Anxiety Disorder
  3. Class
    1. Long acting Benzodiazepine
  4. Pharmacokinetics
    1. Peak plasma concentration: 1-3 hours after oral dose
    2. Half Life: 14 hours
  5. Dosing
    1. Dose: 20 to 40 mg PO tid to qid or 80 mg PO qhs
    2. Maximum Daily Dose: 160 mg
  6. Equivalent Dosing (for Benzodiazepine Withdrawal)
    1. Valium = Halazepam Dose x0.25
    2. Phenobarbital = Halazepam Dose x0.75

halazepam (C0062092)

Definition (NCI) A synthetic benzodiazepine derivative with anxiolytic property. Halazepam potentiates the inhibitory activities of gamma-aminobutyric acid (GABA) by binding to the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the limbic, thalamic, and hypothalamic regions of the central nervous system (CNS). This increases the frequency of chloride channel opening, allowing the flow of chloride ions into the neuron and ultimately leading to membrane hyperpolarization and a decrease in neuronal excitability.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C010175
SnomedCT 63545000, 371367008
LNC LP18083-3, MTHU003364
English 7-chloro-1,3-dihydro-5-phenyl-1- (2,2,2-trifluoroethyl)-2H-1,4-benzodiazepin-2-one, halazepam, halazepam (medication), halazepam [Chemical/Ingredient], Halazepam, Halazepam (substance), Halazepam product (product), Halazepam product, HALAZEPAM
Spanish halazepam, halazepam (producto), halazepam, producto (producto), halazepam, producto, halacepam (sustancia), halacepam
Derived from the NIH UMLS (Unified Medical Language System)

Paxipam (C0722503)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Paxipam
Derived from the NIH UMLS (Unified Medical Language System)

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