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Diazepam
Aka: Diazepam, Valium
- See Also
- Benzodiazepine
- Indications
- Insomnia
- Anxiety Disorder
- Alcohol Withdrawal
- Seizure Disorder
- Musculoskeletal spasm
- Tetanus
- Contraindications
- Acute Narrow Angle Glaucoma
- Untreated Open Angle Glaucoma
- Children under age 6 years
- Pharmacokinetics
- Half Life: 20-90 hours
- Precautions
- Avoid when requiring optimal mental status
- Driving
- Operating machinery
- Use caution if risk of cardiopulmonary depression
- Elderly
- Very ill patients
- Limited pulmonary reserve (e.g. COPD)
- Do not use with other cardiopulmonary depressants
- Alcohol
- Barbiturates
- Intravenous Injection
- Inject intravenously slowly (1 ml per minute)
- Reduce dose to 70% when administering with Narcotic
- Adverse Reactions
- Common General affects
- Drowsiness
- Fatigue
- Ataxia
- Benzodiazepine Dependence with withdrawal symptoms
- Local injection side affects (inject slowly)
- Venous thrombosis
- Phlebitis
- Dosing
- Anxiety Disorder
- Dose: 2 to 10 mg PO bid to qid
- Maximum Daily Dose: 40 mg
- Acute Alcohol Withdrawal
- First day: 10 mg PO tid to qid
- Next days: 5 mg PO tid to qid
- Musculoskeletal spasm
- Dose: 2 to 10 mg PO tid to qid
- Seizure disorder
- Dose: 2 to 10 mg PO qd
- Older patients or with comorbid condition
- Dose: 2 to 2.5 mg PO qd to bid
- Preparations
- Equivalents to 10 mg Diazepam (for withdrawal protocol)
- Alprazolam (Xanax) 1 mg
- Chlordiazepoxide (Librium) 25 mg
- Clonazepam (Klonopin) 4 mg
- Flurazepam (Dalmane) 15 mg
- Halazepam (Paxipam) 40 mg
- Lorazepam (Ativan) 2 mg
- Oxazepam (Serax) 10 mg
- Temazepam (Restoril) 10 mg
- Equivalents to 60 mg Diazepam (for withdrawal protocol)
- Alprazolam (Xanax) 6 mg
- Chlordiazepoxide (Librium) 150 mg
- Clonazepam (Klonopin) 24 mg
- Flurazepam (Dalmane) 90 mg
- Halazepam (Paxipam) 240 mg
- Lorazepam (Ativan) 12 mg
- Oxazepam (Serax) 60 mg
- Temazepam (Restoril) 60 mg