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Citalopram
Aka: Citalopram, Celexa, Escitalopram, Lexapro- Mechanism
- Selective Serotonin Reuptake Inhibitor (SSRI)
- Minimal effects on other neurotransmitters
- Pharmacokinetics
- Half-life: 20 hours
- Indications
- Preparations
- Citalopram (Celexa)
- Tablets: 10, 20 (scored), 40 (scored)
- Oral Solution: 10 mg/5 ml
- Escitalopram (Lexapro)
- Active isomer of racemic Citalopram
- Tablets: 5, 10 (scored), 20 mg (scored)
- Citalopram (Celexa)
- Dosing
- Citalopram (Celexa)
- Starting dose: 20 mg PO qd
- Most effective dose: 40 mg PO qd
- Maximum Dose: 40 mg
- Escitalopram (Lexapro)
- Starting Dose: 10 mg qd (equivalent to 40 mg Celexa)
- Higher dose at 20 mg is not more effective than 10 mg
- Citalopram (Celexa)
- Adverse Effects
- No increased weight gain
- Midway on spectrum between Anxiolytic and anxiogenic
- Similar to Zoloft on this spectrum
- Well tolerated
- Nausea
- May occur initially but is transient
- Consider decreasing dose to 10 mg initially
- Less Sexual Dysfunction than Prozac, Zoloft, Paxil
- Sexual Dysfunction in 10-15% of cases
- Similar to Luvox and Effexor in terms of this effect
- See Antidepressant Induced Sexual Dysfunction
-
Drug Interactions
- Cytochrome P450 2C19 Inhibitors
- Arrhythmia risk: Prolonged QT interval and Torsades de Pointes risk
- Most significant agents
- Agents that do not appear to have significant interactions
- Precautions
- Limit Citalopram to 20 mg daily in those on Omeprazole, Esomeprazole, Oral Contraceptives
- Consider Escitalopram (Lexapro) instead which appears safe to at least 20 mg daily with these agents
- Resources
- FDA Drug Safety Notice
- Cytochrome P450 2C19 Inhibitors
- Resources
- Celexa Website (Forest Pharmaceuticals)
| Medication Costs | ||
|---|---|---|
| Citalopram (on 6/18/2017 at Walmart.com) | ||
| Citalopram 20mg | #30 tablets for $4.00 | $0.13 each |
| Citalopram 20mg | #90 tablets for $10.00 | $0.11 each |
| Citalopram 40mg | #30 tablets for $4.00 | $0.13 each |
| Citalopram 40mg | #90 tablets for $10.00 | $0.11 each |
| citalopram (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
| CITALOPRAM HBR 10 MG TABLET | Generic | $0.03 each |
| CITALOPRAM HBR 10 MG/5 ML SOLN | Generic | $0.22 per ml |
| CITALOPRAM HBR 20 MG TABLET | Generic | $0.03 each |
| CITALOPRAM HBR 40 MG TABLET | Generic | $0.04 each |
| celexa (on 1/1/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
| CELEXA 10 MG TABLET | Generic | $0.03 each |
| CELEXA 20 MG TABLET | Generic | $0.03 each |
| CELEXA 40 MG TABLET | Generic | $0.04 each |
| escitalopram (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
| ESCITALOPRAM 10 MG TABLET | Generic | $0.08 each |
| ESCITALOPRAM 20 MG TABLET | Generic | $0.10 each |
| ESCITALOPRAM 5 MG TABLET | Generic | $0.10 each |
| ESCITALOPRAM OXALATE 5 MG/5 ML | Generic | $0.46 per ml |
| lexapro (on 1/1/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
| LEXAPRO 10 MG TABLET | Generic | $0.08 each |
| LEXAPRO 20 MG TABLET | Generic | $0.10 each |
| LEXAPRO 5 MG TABLET | Generic | $0.10 each |
| LEXAPRO 5 MG/5 ML SOLUTION | Generic | $0.46 per ml |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Citalopram (C0008845) |
|
|---|---|
| Definition (CHV) | a kind of antidepressant drug |
| Definition (CHV) | a kind of antidepressant drug |
| Definition (NCI) | A bicyclic phthalene derivative and selective serotonin reuptake inhibitor (SSRI), with antidepressant and anxiolytic activities. Citalopram selectively inhibits the neuronal reuptake of the neurotransmitter serotonin (5-HT) in presynaptic cells in the central nervous system, thereby increasing levels of 5-HT within the synaptic cleft and enhancing the actions of serotonin on its receptors. Increased serotonergic neurotransmission results in antidepressive and anxiolytic effects. |
| Definition (MSH) | A furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition. |
| Definition (CSP) | selective neuronal serotonin reuptake inhibitor and a clinically effective antidepressant with tolerable side effects; effective in reducing ethanol uptake in alcoholics. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D015283 |
| SnomedCT | 321986007, 372596005 |
| LNC | LP20806-3, MTHU012380 |
| English | Citalopram, Cytalopram, 5-Isobenzofurancarbonitrile, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydro-, CITALOPRAM, Citalopram [Chemical/Ingredient], cytalopram, Nitalapram, 1,3-Dihydro-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-5-isobenzofurancarbonitrile, citalopram, Citalopram (product), Citalopram (substance) |
| Swedish | Citalopram |
| Czech | citalopram |
| Finnish | Sitalopraami |
| Russian | TSITALOPRAM, ЦИТАЛОПРАМ |
| Japanese | シタロプラム |
| Polish | Citalopram |
| Spanish | citalopram (producto), citalopram (sustancia), citalopram, Citalopram |
| French | Citalopram |
| German | Citalopram |
| Italian | Citalopram |
| Portuguese | Citalopram |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Celexa (C0719199) |
|
|---|---|
| Definition (CHV) | depression treatment drug |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| English | Celexa, citalopram hydrobromide (Celexa), CeleXA |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Escitalopram (C1099456) |
|
|---|---|
| Definition (NCI_NCI-GLOSS) | A drug used to treat depression and certain anxiety disorders. It belongs to the family of drugs called selective serotonin reuptake inhibitors (SSRIs). |
| Definition (NCI) | The active S-stereoisomer of the selective serotonin reuptake inhibitor (SSRI) citalopram with antidepressant, anti-obsessive-compulsive and antibulimic properties. Escitalopram inhibits the reuptake of the neurotransmitter serotonin (5-HT) at the serotonin reuptake pump of the neuronal membrane of the presynaptic cell, thereby increasing levels of 5-HT within the synaptic cleft and enhancing the actions of serotonin on 5HT1A autoreceptors. Unlike other SSRIs, escitalopram appears to not only bind to a primary high-affinity site on the serotonin transporter protein but also to a secondary lower-affinity allosteric site that is considered to stabilize and prolong drug binding. |
| Definition (MSH) | S-enantiomer of citalopram. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D015283 |
| SnomedCT | 395246009, 400447003 |
| LNC | LP31801-1, MTHU016070 |
| French | Escitalopram |
| English | S(+)-Citalopram, (S)-Citalopram, ESCITALOPRAM, escitalopram, Escitalopram (product), Escitalopram (substance), Escitalopram |
| Japanese | エスシタロプラム |
| Czech | escitalopram |
| Spanish | escitalopram (producto), escitalopram (sustancia), escitalopram |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Lexapro (C1170371) |
|
|---|---|
| Definition (CHV) | a drug used to treat depression and anxiety |
| Definition (MSH) | Trade name of escitalopram, the active S-enantiomer of the racemic citalopram. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D015283 |
| English | Lexapro |
| Czech | Lexapro |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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