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Amitriptyline
Aka: Amitriptyline, Elavil- Background
- Cost: $5.30 per month
- Indications
- Pharmacokinetics
- Serum Half Life: 21 hours
- Therapeutic plasma level: 110 to 250
- Dosing: Insomnia
- Initial: 25 mg PO qhs
- Morning Hangover Effect: Taper to 10 mg PO qhs
- Dosing: Depression (listed for historical purposes only)
- Avoid for Depression given adverse effects
- SSRIs and other new Antidepressants are preferred
- Dose: 150-300 mg qhs
- Adverse effects
- See Tricyclic Antidepressants
- Significant adverse effects
- Sedation and morning grogginess
- Anticholinergic Symptoms
- Orthostatic Hypotension
- Cardiac arrhythmia
- Weight gain
- Precautions
| Medication Costs | ||
|---|---|---|
| Amitriptyline (on 6/18/2017 at Walmart.com) | ||
| Amitriptyline 100mg | #30 tablets for $4.00 | $0.13 each |
| Amitriptyline 100mg | #90 tablets for $10.00 | $0.11 each |
| Amitriptyline 10mg | #30 tablets for $4.00 | $0.13 each |
| Amitriptyline 10mg | #90 tablets for $10.00 | $0.11 each |
| Amitriptyline 25mg | #30 tablets for $4.00 | $0.13 each |
| Amitriptyline 25mg | #90 tablets for $10.00 | $0.11 each |
| Amitriptyline 50mg | #30 tablets for $4.00 | $0.13 each |
| Amitriptyline 50mg | #90 tablets for $10.00 | $0.11 each |
| Amitriptyline 75mg | #30 tablets for $4.00 | $0.13 each |
| Amitriptyline 75mg | #90 tablets for $10.00 | $0.11 each |
| amitriptyline (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
| AMITRIPTYLINE HCL 10 MG TAB | Generic | $0.12 each |
| AMITRIPTYLINE HCL 100 MG TAB | Generic | $0.90 each |
| AMITRIPTYLINE HCL 150 MG TAB | Generic | $1.27 each |
| AMITRIPTYLINE HCL 25 MG TAB | Generic | $0.23 each |
| AMITRIPTYLINE HCL 50 MG TAB | Generic | $0.46 each |
| AMITRIPTYLINE HCL 75 MG TAB | Generic | $0.73 each |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Amitriptyline (C0002600) |
|
|---|---|
| Definition (NCI_NCI-GLOSS) | A drug that is used to treat depression and may be given to treat anxiety, sleep disorders, and pain. It is also being studied in an oral or gel form in the treatment of nerve pain caused by chemotherapy. Amitriptyline is a type of tricyclic antidepressant. |
| Definition (NCI) | A derivative of dibenzocycloheptadiene and a tricyclic antidepressant. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity. |
| Definition (MSH) | Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines. |
| Definition (CSP) | tricyclic antidepressant with anticholinergic and sedative properties; it appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters; it also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D000639 |
| SnomedCT | 372726002, 40589005 |
| LNC | LP14983-8, MTHU004907 |
| English | Amitriptyline, amitriptyline, 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-, Amitriptyline [Chemical/Ingredient], AMITRIPTYLINE, Amitriptyline (product), Amitriptyline (substance) |
| Swedish | Amitriptylin |
| Czech | amitriptylin |
| Finnish | Amitriptyliini |
| Russian | TRIPTIZOL, TEPERIN, AMITRIPTILIN, АМИТРИПТИЛИН, ТЕПЕРИН, ТРИПТИЗОЛ |
| Japanese | アミトリプチリン, 塩酸アミトリプチリン |
| Croatian | AMITRIPTILIN |
| Polish | Amitryptylina |
| Spanish | amitriptilina (producto), amitriptilina (sustancia), amitriptilina, Amitriptilina |
| French | Amitriptyline |
| German | Amitriptylin |
| Italian | Amitriptilina |
| Portuguese | Amitriptilina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Elavil (C0087119) |
|
|---|---|
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D000639 |
| English | Cahill May Roberts Brand of Amitriptyline Embonate, Cahill May Roberts Brand of Amitriptyline Hydrochloride, DDSA Brand of Amitriptyline Hydrochloride, Merck Sharp & Dohme Brand of Amitriptyline Embonate, Merck Sharp & Dohme Brand of Amitriptyline Hydrochloride, Tryptanol, Zeneca Brand of Amitriptyline Hydrochloride, Elavil, Tryptizol |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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