//fpnotebook.com/
Neurotransmitter Physiology
Aka: Neurotransmitter Physiology
- Physiology: GABA and NMDA
- N-methyl-D-Aspartate (NMDA) receptor
- Glutamate binds NMDA receptors and results in excitation
- NMDA receptors are up regulated in chronic Alcohol Abuse
- NMDA Antagoists include Ketamine
- Gamma-aminobutyric acid (GABA) receptor
- GABA Agonists bind GABA receptors and resul in inhibition
- GABA Receptors are down regulated in chronic Alcohol Abuse
- Physiology: Neurotransmitter at Synapse
- Medications affecting Precursor Uptake
- L-Phenylalanine
- L-Tyrosine
- L-Dopa
- Dopamine (DA)
- Norepinephrine (NE)
- Epinephrine (E)
- L-Tryptophan
- 5-Hydroxytryptophan,
- 5-Hydroxytryptamine (5-HT) = Serotonin
- Choline/lecithin + AcetylCoA => Acetylcholine (Ach)
- Medications affecting Synthetic Enzymes
- Metyrosine (Demser) blocks Tyrosine hydroxylase
- Decrease DA, NE, E, 5HT
- Methyldopa (Aldomet) blocks decarboxylation
- Decrease DA, NE, E, 5HT
- Medications affecting Transfer into Vesicle
- No clinically available drugs
- Medications affecting Vesicle storage
- Reserpine (Serpasil) depletes storage
- Decreases DA, NE, E, 5HT
- Medications affecting Vesicle mobilization
- Affects Nerve Impulse Conduction Vesicle release
- Electroconvulsive Therapy decreases DA, NE, E, 5HT
- Medications affecting Post-synaptic receptors
- Reversible receptor blockade by Neuroleptics (Haldol)
- Medications affecting Neurotransmitter reuptake
- Reuptake inhibition by all Antidepressants (Prozac)
- Medications affecting Neurotransmitter breakdown
- No drugs available
- Medications affecting Neurotransmitter dilution
- No drugs available
- Medications affecting Neurotransmitter breakdown
- Monamine oxidase inhibitor (MOAi) (Parnate, Nardil)
- Tacrine Inhibits Acetylcholinesterase
- Increases Acetylcholine
- Physiology: Neurotransmitter Theory applied to Psychiatric Medication
- Neuroleptics
- Deplete Neurotransmitter Stores
- Rauwolfia alkaloids (e.g. Reserpine)
- Phenothiazine: Chlorpromazine (Thorazine)
- Thioxanthenes: thiothixene (Navane)
- Butyrophenones: Haloperidol (Haldol)
- Receptor blockade
- Lithium Carbonate
- Interferes with Neurotransmitter storage Na-K Pump
- Stimulants
- Mimic neurotransmitter at storage or Receptor sites
- Amphetamines: Methamphetamine (Methedrine)
- Benzyl-piperidines: Methylphenidate (Ritalin)
- Antidepressants: MAO inhibitors
- Tranylcypromine (Parnate)
- Inactivate MAO
- Polycyclic: Imipramine HCl (Tofranil)
- Inhibit MAO reuptake