Prevention Book


Charlson Comorbidity Index

Aka: Charlson Comorbidity Index, Comorbidity-Adjusted Life Expectancy
  1. Indication
    1. Assess whether a patient will live long enough to benefit from a specific screening measure or medical intervention
  2. Scoring: Comorbidity Component (Apply 1 point to each unless otherwise noted)
    1. Myocardial Infarction
    2. Congestive Heart Failure
    3. Peripheral Vascular Disease
    4. Cerebrovascular Disease
    5. Dementia
    6. COPD
    7. Connective Tissue Disease
    8. Peptic Ulcer Disease
    9. Diabetes Mellitus (1 point uncomplicated, 2 points if end-organ damage)
    10. Moderate to Severe Chronic Kidney Disease (2 points)
    11. Hemiplegia (2 points)
    12. Leukemia (2 points)
    13. Malignant Lymphoma (2 points)
    14. Solid Tumor (2 points, 6 points if metastatic)
    15. Liver Disease (1 point mild, 3 points if moderate to severe)
    16. AIDS (6 points)
  3. Scoring: Age
    1. Correction
      1. Corrected 7/2014 (based on 1996 paper)
      2. Age-based scoring starts at age 50 years (not age 40 years)
    2. Scoring
      1. Age <50 years: 0 points
      2. Age 50-59 years: 1 points
      3. Age 60-69 years: 2 points
      4. Age 70-79 years: 3 points
  4. Interpretation
    1. Calculate Charlson Score or Index (i)
      1. Add Comorbidity score to age score
      2. Total denoted as 'i' below
    2. Calculate Charlson Probablity (10 year mortality)
      1. Calculate Y = e^(i * 0.9)
      2. Calculate Z = 0.983^Y
      3. where Z is the 10 year survival
  5. References
    1. Charlson (1987) J Chron Dis 40: 373–83 [PubMed]
    2. Charlson (1994) J Clin Epidemiol 47(11): 1245–51 [PubMed]

Survival Rate (C0038954)

Definition (NCI_NCI-GLOSS) The percentage of people in a study or treatment group who are alive for a certain period of time after they were diagnosed with or treated for a disease, such as cancer. The survival rate is often stated as a five-year survival rate, which is the percentage of people in a study or treatment group who are alive five years after diagnosis or treatment.
Definition (MSH) The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Concepts Quantitative Concept (T081)
MSH D015996
English Rate, Survival, Rates, Survival, Survival Rate, Survival Rates, survival rate, survival rates, overall survival rate
French Taux de survie
Swedish Överlevnadsfrekvens
Czech přežívající - četnost
Finnish Elossaololuku
Japanese 累積生存率, 生存率, 残存者取得権
Polish Okres przeżycia, Odsetek przeżyć, Przeżycie chorych, Średni czas przeżycia, Przeżywalność, Współczynnik przeżycia
Norwegian Overlevelsesrate
Portuguese Taxa de Sobrevivência, Taxa de Sobrevida
German Überlebensrate
Italian Tasso di sopravvivenza
Dutch Overlevingscijfer
Spanish Tasa de Supervivencia
Derived from the NIH UMLS (Unified Medical Language System)

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