Prevention Book


Test Sensitivity

Aka: Test Sensitivity, False Negative Rate
  1. See Also
    1. Screening Test
    2. Contingency Grid or Cross Tab (includes Statistics Example)
    3. Bayes Theorem (Bayesian Statistics)
    4. Fagan Nomogram
    5. Experimental Error (Experimental Bias)
    6. Lead-Time Bias
    7. Length Bias
    8. Selection Bias (Screening Bias)
    9. Likelihood Ratio (Positive Likelihood Ratio, Negative Likelihood Ratio)
    10. Number Needed to Screen (Number Needed to Treat, Absolute Risk Reduction, Relative Risk Reduction)
    11. Negative Predictive Value
    12. Positive Predictive Value
    13. Pre-Test Odds or Post-Test Odds
    14. Receiver Operating Characteristic
    15. Test Specificity (False Positive Rate)
    16. U.S. Preventive Services Task Force Recommendations
  2. Definition
    1. Screening Test's ability to identify true disease
    2. A Test with high sensitivity has few false negatives
    3. Independent of disease Prevalence in the community
    4. Sensitive Tests allow user to rule out a condition (mnemonic "SNout")
  3. Calculation
    1. Test Sensitivity
      1. True positive tests per total affected patients tested
      2. Test Sensitivity = P(positive test | disease)
        1. Where P (A | B) = Probability of A given B
      3. Expressed as a percentage
    2. False Negative Rate
      1. True cases missed by the Screening Test (test negative despite presence of condition)
      2. False Negative Rate = 1 - Test Sensitivity
  4. Example: A new Screening Test for Crohn's Disease
    1. Patients with known Crohn's Disease tested: 45
    2. Patients with known Crohn's Disease who have a positive test: 36
    3. Sensitivity = 36/45 or 80%
  5. References
    1. Hennekens (1987) Epidemiology Medicine, p.327-47
    2. Gates (2001) Am Fam Physician 63(3):513-22 [PubMed]
    3. MacLean (1996) Med Clin North Am 80(1):1-14 [PubMed]
    4. Nielsen (1999) Med Clin North Am 83(6):1323-37 [PubMed]

sensitivity of measurement (C0681900)

Concepts Quantitative Concept (T081)
English sensitivity of measurement
Derived from the NIH UMLS (Unified Medical Language System)

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