Prevention Book


Negative Predictive Value

Aka: Negative Predictive Value
  1. See Also
    1. Screening Test
    2. Contingency Grid or Cross Tab (includes Statistics Example)
    3. Bayes Theorem (Bayesian Statistics)
    4. Fagan Nomogram
    5. Experimental Error (Experimental Bias)
    6. Lead-Time Bias
    7. Length Bias
    8. Selection Bias (Screening Bias)
    9. Likelihood Ratio (Positive Likelihood Ratio, Negative Likelihood Ratio)
    10. Number Needed to Screen (Number Needed to Treat, Absolute Risk Reduction, Relative Risk Reduction)
    11. Positive Predictive Value
    12. Pre-Test Odds or Post-Test Odds
    13. Receiver Operating Characteristic
    14. Test Sensitivity (False Negative Rate)
    15. Test Specificity (False Positive Rate)
    16. U.S. Preventive Services Task Force Recommendations
  2. Definition
    1. Patients with negative test that do not have disease
    2. P(No Disease | negative test )
    3. Assesses reliability of negative test
  3. Indications
    1. Puts Test Sensitivity in context of disease Prevalence
    2. Lower disease Prevalence results in higher NPV
      1. Test Sensitivity effect minimized at low Prevalence
      2. False Negatives decrease substantially
      3. Results in more reliable negative test
  4. Calculation
    1. NPV = (True negative) / (true and False Negatives)

Negative Predictive Value of Diagnostic Test (C1513918)

Definition (NCI) The probability that an individual is not affected with the condition when a negative test result is observed. This measure of accuracy should only be used if the data on the prevalence of condition of interest in given population is available. NPVDT can be determined by calculating: number of true negative results divided by the sum of true negative results plus number of false negative results.
Definition (NCI_NCI-GLOSS) The likelihood that an individual with a negative test result is truly unaffected and/or does not have the particular gene mutation in question.
Concepts Quantitative Concept (T081)
English Negative Predictive Value of Diagnostic Test, NPV, negative predictive value
Derived from the NIH UMLS (Unified Medical Language System)

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