Pharmacology Book

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Cytochrome P-450 1A2 Isoenzyme

Aka: Cytochrome P-450 1A2 Isoenzyme, CYP1A2
  1. Interactions: Metabolized by CYP1A2 (Substrates)
    1. Neuropsychiatric drugs
      1. Amitriptyline (Elavil)
      2. Clomipramine (Anafranil)
      3. Imipramine (Tofranil)
      4. Clozapine (Clozaril)
      5. Tacrine (Cognex)
    2. Cardiopulmonary Drugs
      1. Propranolol (Inderal)
      2. Theophylline
    3. Miscellaneous
      1. Acetaminophen (Tylenol)
      2. Caffeine
      3. Warfarin (Coumadin)
  2. Interactions: Inhibitor of CYP1A2
    1. Neuropsychiatric Drugs
      1. Fluvoxamine (Luvox)
      2. Tacrine (Cognex)
    2. Cardiopulmonary Drugs
      1. Verapamil
      2. Diltiazem
      3. Amiodarone (inhibitor)
    3. Antibiotics
      1. Enoxacin: Inhibitor
      2. Ciprofloxacin: Inhibitor
      3. Norfloxacin: Inhibitor
    4. Miscellaneous Drugs
      1. Grapefruit juice
      2. Cimetidine
      3. Ticlopidine
  3. Interactions: Inducers of CYP1A2
    1. Neuropsychiatric drugs
      1. Phenobarbital
      2. Phenytoin
    2. Antibiotics
      1. Rifampin
    3. Miscellaneous
      1. Charcoal broiled beef
      2. Tobacco exposure (e.g. Cigarette smoke)
      3. Cruciferous vegetables
      4. Omeprazole (Prilosec)

Cytochrome P-450 CYP1A2 (C0207509)

Definition (NCI) Cytochrome P450 1A2 (515 aa, ~58 kDa) is encoded by the human CYP1A2 gene. This protein is involved in the hydroxylation of fatty acids, steroids and xenobiotics.
Definition (MSH) A cytochrome P450 enzyme subtype that has specificity for relatively planar heteroaromatic small molecules, such as CAFFEINE and ACETAMINOPHEN.
Concepts Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSH D019388
SnomedCT 424020001
English Cytochrome P 450d, Cytochrome P-450 LM(4), Cytochrome P-450d, CYP1A2, CYP 1A2, CYP1A2, Cytochrome P-450, Caffeine Demethylase, Cytochrome P 450 CYP1A2, Cytochrome P-450 LM4, Cytochrome P450 1A2, Demethylase, Caffeine, O-Dealkylase, Phenacetin, Phenacetin O Dealkylase, Phenacetin O-Dealkylase, Cytochrome p450 CYP1A2 enzyme, Cytochrome p450 CYP1A2 enzyme (substance), CYTOCHROME P 450 CYP 001 A 002, CYP 001 A 002, Cytochrome P-450 CYP1A2 [Chemical/Ingredient], cyp1a2, Cytochrome P450, Family 1, Subfamily A, Polypeptide 2, Cytochrome P450-P3, Cytochrome P450 4, Cytochrome P(3)450, CYPIA2, Cytochrome P 450 LM4, P-450 LM4, Cytochrome, Cytochrome P-450 CYP1A2, Flavoprotein-Linked Monooxygenase, Cytochrome P-450, Aromatic Compound-Inducible, Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 2, Dioxin-Inducible P3-450, EC 1.14.14.1, Microsomal Monooxygenase, P(3)450, P450 4, P450 Form 4, P450-P3, Aryl Hydrocarbon Hydroxylase, Xenobiotic Monooxygenase
Swedish Cytokrom P-450 CYP1A2
Spanish enzima CYP1A2 de citocromo p450, enzima CYP1A2 de citocromo p450 (sustancia), CYP1A2, Citocromo P-450 CYP1A2, Fenacetina O-Dealcilasa
Czech cytochrom P-450 CYP1A2
Finnish Sytokromi P-450 CYP1A2
Russian TSITOKHROM P-450 CYP1A2, FENATSETIN-O-DEALKILAZA, ФЕНАЦЕТИН-O-ДЕАЛКИЛАЗА, ЦИТОХРОМ P-450 CYP1A2
Japanese シトクロムP-450CYP1A2, カフェインデメチラーゼ, チトクロームP-450CYP1A2, フェナセチンO-デアルキラーゼ
Italian Citocromo P-450d, Citocromo P-450 LM4, CYP1A2, Citocromo P-450 LM(4), CYP 1A2, Citocromo P450 1A2, Fenacetina o-dealchilasi, Citocromo P-450 CYP1A2
German CYP 001 A 002, CYTOCHROM P 450 CYP 001 A 002, CYP1A2, Cytochrom P-450 CYP1A2, Phenacetin-O-Dealkylase
French Cytochrome P450 1A2, Phénacétine O-désalkylase, CYP 1A2, CYP1A2, Cytochrome P-450 CYP1A2
Polish Cytochrom P-450 CYP1A2
Norwegian Cytokrom P-450d, Koffein-demetylase, Cytokrom P-450 CYP1A2, CYP1A2, Cytokrom P-450 LM(4), Cytokrom P450 1A2, CYP 1A2, Phenacetin O-dealkylase
Portuguese CYP1A2, Citocromo P-450 CYP1A2, Fenacetina O-Desalquilase
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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