Pharmacology Book



Aka: Tapentadol, Nucynta
  1. Mechanism
    1. Mu-Opioid receptor agonist
    2. Norepinephrine reuptake inhibitor
  2. Indications
    1. Moderate to severe acute pain
  3. Contraindications
    1. Severe renal Impairment
    2. Severe hepatic Impairment
  4. Efficacy
    1. As effective as Oxycodone
    2. Less Nausea, Vomiting and Constipation than Oxycodone
  5. Drug Interactions
    1. Serotonin Syndrome risk
  6. Adverse Reactions
    1. Seizures
    2. Anaphylactoid Reaction
    3. Respiratory Depression
  7. Preparations
    1. Schedule II Controlled Substance
    2. Immediate release
      1. Tapentadol 50-100 mg orally every 4-6 hours as needed (up to 600 mg/day)
      2. Decrease dose to 50 mg every 8 hours if moderate hepatic Impairment
    3. Extended release
      1. Tapentadol XR 50 mg orally twice daily (and titrate up to 250 mg twice daily)
      2. May start higher if transitioning from other Opioids
  8. References
    1. Tarascon pharmacopeia (2013)
    2. Hartrick (2011) CNS Drugs 25(5): 359-70 [PubMed]
Medication Costs
nucynta (on 4/19/2017 at Medicaid.Gov Pharmacy Drug pricing)
NUCYNTA 100 MG TABLET $7.89 each
NUCYNTA 50 MG TABLET $5.06 each
NUCYNTA 75 MG TABLET $5.90 each
NUCYNTA ER 100 MG TABLET $10.13 each
NUCYNTA ER 150 MG TABLET $13.04 each
NUCYNTA ER 200 MG TABLET $16.63 each
NUCYNTA ER 250 MG TABLET $20.81 each
NUCYNTA ER 50 MG TABLET $5.49 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

tapentadol (C2001271)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C523979
SnomedCT 441757005, 442004000
LNC LP99218-7, MTHU035629
English Tapentadol, Tapentadol (product), Tapentadol (substance), TAPENTADOL, tapentadol, 3-((1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl)phenol
Spanish tapentadol (producto), tapentadol, tapentadol (sustancia)
Derived from the NIH UMLS (Unified Medical Language System)

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