Pharmacology Book


Topical NSAID

Aka: Topical NSAID, Diclofenac Topical, Diclofenac Gel, Voltaren Emulgel, Diclofenac Solution, Pennsaid, Diclofenac Patch, Flector Patch
  1. See Also
    1. NSAID
    2. Topical Analgesic
  2. Preparations: Diclofenac
    1. Diclofenac Solution (Pennsaid 1.5%)
    2. Diclofenac Gel (Voltaren Gel 1.5%)
    3. Diclofenac Patch (Flector Patch)
  3. Preparations: Other NSAIDs
    1. Pharmacy may compound other NSAIDs (e.g. ketoprofen, piroxicam, Ibuprofen)
  4. Dosing: Diclofenac 1% gel applied to affected joints
    1. Will be OTC without a prescription in 2020
    2. Measure gel on a dosing card and massage into affected area
      1. Two grams is 2.25 inches (6 cm) long when squeezed from tube
      2. Four grams is 4.5 inches (11.5 cm) long when squeezed frin tube
    3. Overall maximum: 32 grams/day over all affected joints
    4. Elbow, hand or wrist: 2 grams applied up to 4 times daily (maximum 8 grams/day/joint)
    5. Knee, ankle or foot: 4 grams applied up to 4 times daily (maximum 16 grams/day/joint)
      1. Not recommended for larger joints
    6. May use for up to 7 days
  5. Precautions
    1. Despite low absorption, cardiovascular and renal risks may still pertain to Topical NSAIDs
    2. Do not combine with other topicals or other NSAID forms
    3. Do not apply heat to application site
    4. Avoid washing area or showering for at least one hour after application
  6. Pharmacokinetics
    1. Systemic absorption <10% (gel may be 6%)
  7. Adverse effects
    1. Local skin reactions (Dry Skin or local irritation)
    2. Besides local reactions, systemic adverse event rate is very low compared with oral NSAIDs
      1. Klinge (2013) Phys Sportsmed 41(2): 64-74 +PMID:23703519 [PubMed]
  8. Efficacy
    1. Knee Osteoarthritis pain relief was equivalent for Topical diclofenac as for oral diclofenac
      1. However, topical caused only local skin irritation, and oral diclofenac had gastrointestinal adverse effects
      2. Tugwell (2004) J Rheumatol 31(10): 2002-12 +PMID:15468367 [PubMed]
    2. Acute musculoskeletal pain reduced by >50% with Topical Steroid (Number Needed to Treat 1.8)
      1. Derry (2015) Cochrane Database Syst Rev (6):CD007402 +PMID:26068955 [PubMed]
  9. Contraindications
    1. Absolute
      1. CABG history
      2. Asthma or aspirin Hypersensitivity
      3. Advanced renal disease
    2. Relative (use with caution in this group)
      1. Known cardiovascular disease
      2. Known Peptic Ulcer Disease (however topical diclofenac did not appear to increase ulcer risk)
      3. Hypertension (however topical diclofenac did not appear to increase Blood Pressure)
      4. Hepatic insufficiency
      5. Advanced Chronic Kidney Disease
      6. Congestive Heart Failure or other edematous condition
  10. References
    1. (2016) Presc Lett 23(1): 2
    2. DeLaney in Herbert (2017) EM:Rap 17(11): 11-2
Medication Costs
pennsaid (on 12/30/2016 at Medicaid.Gov Pharmacy Drug pricing)
PENNSAID 2% PUMP $19.65 per gram
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Diclofenac Topical Product (C0358504)

Concepts Clinical Drug (T200)
SnomedCT 349350007
English Topical diclofenac, diclofenac topical, Diclofenac Topical Product, Topical form diclofenac (product), Topical form diclofenac, Topical diclofenac (product), Topical diclofenac (substance)
Spanish diclofenaco, forma farmacéutica tópica (producto), diclofenac tópico, diclofenaco, forma farmacéutica tópica, diclofenac tópico (producto)
Derived from the NIH UMLS (Unified Medical Language System)

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