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Hydromorphone
Aka: Hydromorphone, Dilaudid- See Also
- Dosing: Adults (or children over age 12 years)
- Oral
- Hydromorphone 2-4 mg orally as needed every 4-6 hours
- Parenteral: SC or IM
- Hydromorphone 0.5 to 2 mg SC or IM as needed every 4-6 hours
- Parenteral: IV
- Hydromorphone 0.5 mg slow IV over 2-5 min every 15 min as needed for 3 doses or
- Hydromorphone 1 mg slow IV over 2-5 min every 2 hours as needed
- Oral
- Dosing: Children (under age 12 years)
- Oral
- Hydromorphone 0.03 to 0.08 mg/kg up to 2-4 mg orally as needed every 4-6 hours
- Parenteral: IV
- Hydromorphone 0.015 mg/kg/dose up to 0.5 to 2 mg slow IV over 2-5 min as needed every 4-6 hours
- Oral
- Adverse Effects
- Precautions
- Hydromorphone 1 mg IV is equivalent to 7 mg Morphine Sulfate IV
- Hydromorphone more easily crosses blood-brain barrier than other Opioids
- Risk of excessive sedation and respiratory depression
- Hydromorphone is renally excreted (clearance may be delayed 40 hours in Renal Failure)
| Medication Costs | ||
|---|---|---|
| hydromorphone (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
| HYDROMORPHONE 1 MG/ML SOLUTION | Generic | $0.30 per ml |
| HYDROMORPHONE 2 MG TABLET | Generic | $0.08 each |
| HYDROMORPHONE 2 MG/ML VIAL | Generic | $1.05 per ml |
| HYDROMORPHONE 3 MG SUPPOS | Generic | $9.58 each |
| HYDROMORPHONE 4 MG TABLET | Generic | $0.09 each |
| HYDROMORPHONE 5 MG/5 ML SOLN | Generic | $0.30 per ml |
| HYDROMORPHONE 8 MG TABLET | Generic | $0.31 each |
| HYDROMORPHONE HCL ER 12 MG TAB | Generic | $10.73 each |
| HYDROMORPHONE HCL ER 16 MG TAB | Generic | $18.78 each |
| HYDROMORPHONE HCL ER 32 MG TAB | Generic | $40.10 each |
| HYDROMORPHONE HCL ER 8 MG TAB | Generic | $8.40 each |
| dilaudid (on 5/15/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
| DILAUDID 5 MG/5 ML ORAL LIQUID | Generic | $0.30 per ml |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Hydromorphone (C0012306) |
|
|---|---|
| Definition (NCI) | The hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons. |
| Definition (NCI_NCI-GLOSS) | A drug used to relieve pain. |
| Definition (MSH) | An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D004091 |
| SnomedCT | 387485001, 44508008, 414428000, 83929000 |
| LNC | LP16162-7, MTHU007189 |
| English | Dihydromorphinone, Hydromorphon, Hydromorphone, Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, (5alpha)-, hydromorphone (medication), Hydromorphone [Chemical/Ingredient], HYDROMORPHONE, HYDROmorphone, (-)-Hydromorphone, hydromorphone, Hydromorphone (substance), dihydromorphinone, hydromorphon, Hydromorphone (product) |
| Swedish | Hydromorfon |
| Spanish | dihidromorfinona, Hidromorfona, hidromorfona (sustancia), hidromorfona, hidromorfona (producto), Dihidromorfinona |
| Czech | dihydromorfinon |
| Finnish | Hydromorfoni |
| Russian | DIGIDROMORFINON, GIDROMORFON, LAUDAKON, ГИДРОМОРФОН, ДИГИДРОМОРФИНОН, ЛАУДАКОН |
| Japanese | ヒドロモルフォン, ラウダコン, ジヒドロモルフィノン, ヒドロモルホン |
| Italian | Diidromorfinone, Idromorfone |
| Polish | Hydromorfon, Dwuhydromorfinon, Dihydromorfinon, Dilavdit, Lavdacon |
| Portuguese | Di-Hidromorfinona, Hidromorfona |
| French | Dihydromorphinone |
| German | Dihydromorphinon, Hydromorphone, Hydromorphon |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Dilaudid (C0728755) |
|
|---|---|
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D004091 |
| English | dilaudid, Dilaudid |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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