Pharmacology Book


Peppermint Oil

Aka: Peppermint Oil, Mentha x piperita, Menthol
  1. Indications
    1. Pain Dominant Irritable Bowel Syndrome (IBS)
      1. Relaxes gastrointestinal Smooth Muscle
      2. Reduces pain, distention and Flatulence
      3. Liu (1997) J Gastroenterol 32:765-8 [PubMed]
      4. Kline (2001) J Pediatr 138:125-8 [PubMed]
    2. Reduction of spasm related to Colonoscopy, Barium Enema
      1. Asao (2003) Clin Radiol 58:301-5 [PubMed]
    3. Non-Ulcer Dyspepsia
      1. Melzer (2004) Aliment Pharmacol Ther 20:1279-87 [PubMed]
    4. Tension Headaches (Topical 10% Peppermint Oil)
      1. Gobel (1994) Cephalgia 14:228-34 [PubMed]
  2. Contraindications
    1. General
      1. Contraindications apply to doses listed below
      2. Tea is unlikely to cause any serious adverse effects
    2. Pregnancy
      1. May cause uterine bleeding
    3. Hiatal Hernia or severe Gastroesophageal Reflux
    4. Cholecystitis or Cholelithiasis
  3. Adverse Effects
    1. Gastroesophageal Reflux
      1. Peppermint decreases LES pressure
    2. Perianal burning
    3. Blurred Vision
    4. Nausea or Vomiting
  4. Dosing
    1. Oral enteric coated oil (for gastrointestinal symptoms)
      1. Adult: 0.2 to 0.4 ml PO tid
      2. Child: 0.1 to 0.2 ml PO tid (if over age 8 years)
    2. Topical Peppermint Oil 10% (for Tension Headache)
      1. Applied to area of Headache
  5. References
    1. Kligler (2007) Am Fam Physician 75(7):1027-30 [PubMed]

Menthol (C0025368)

Definition (NCI) An organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to pharmaceuticals and foods, menthol functions as a fortifier for peppermint flavors. It also has a counterirritant effect on skin and mucous membranes, thereby producing a local analgesic or anesthetic effect.
Definition (NCI_NCI-GLOSS) A substance that comes from mint oils or is made in the laboratory. It is used to relieve itching and to treat problems in the upper respiratory tract. Menthol causes a cooling sensation when eaten or put on the skin and it acts as a mild pain killer. It is found in nasal sprays, cough drops, inhalers, creams, and lotions. It is also used as a flavor in many food and oral hygiene products.
Definition (MSH) An alcohol produced from mint oils or prepared synthetically.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008610
SnomedCT 387414008, 73170009
LNC LP19140-0, MTHU007385
English Cyclohexanol, 5-methyl-2-(1-methylethyl)-, menthol (medication), Menthol, Menthol [Chemical/Ingredient], MENTHOL, menthol, Menthol (product), Menthol (substance)
Swedish Mentol
Czech menthol
Finnish Mentoli
Japanese メントール, 1-メントール
Croatian MENTOL
Polish Sześciowodorotymol, Mentol
Spanish mentol (producto), mentol (sustancia), mentol, Mentol
French Menthol
German Menthol
Italian Mentolo
Portuguese Mentol
Derived from the NIH UMLS (Unified Medical Language System)

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