Pharmacology Book



Aka: Feverfew, Tanacetum parthenium
  1. Indications (Purported uses)
    1. Migraine Headache prevention
  2. Efficacy
    1. Some studies support benefit for Migraine prevention
    2. No benefit in Rheumatoid Arthritis
  3. Mechanism
    1. Inhibits Prostaglandin synthesis
    2. Serotonin antagonist
    3. Inhibits Platelet aggregation
  4. Dosing
    1. Standard extract 125 mg (at least 0.2% parthenolide)
  5. Adverse Effects
    1. Bleeding Diathesis due to Platelet Dysfunction
  6. Contraindications
    1. Pregnancy
      1. Feverfew may induce Menstruation
    2. Concurrent Anticoagulant use or peri-operative
      1. Feverfew increases bleeding risk
  7. References
    1. Shaughnessy (1997) Fam Practice Recert 19(10):53-6
    2. Zink (1998) Am Fam Physician 58(5): 1133-40 [PubMed]

feverfew extract (C0376266)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Feverfew Extract, feverfew extract, feverfew (medication), Tanacetum Parthenium, Feverfew, TANACETUM PARTHENIUM, feverfew, FEVERFEW, Tanacetum parthenium extract, FEVERFEW EXTRACT
Derived from the NIH UMLS (Unified Medical Language System)

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