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Evening Primrose Oil
Aka: Evening Primrose Oil, Oenothera biennis
- Mechanism
- Seeds contain Essential Fatty Acid
- Linoleic Acid
- Gamma-linolenic acid (GLA), a Omega 6 Fatty Acid
- Linoleic Acid is precursor to Prostaglandin E
- May replace deficiency in Premenstrual Syndrome
- Contraindications
- Seizure Disorder
- Concurrent Antipsychotic Medication
- Indications: Current use (preliminary studies suggest it is likely ineffective for most proposed uses)
- Mastalgia (especially cyclical Breast Pain)
- Premenstrual Syndrome
- Menopause
- Other experimental areas
- Atopic Dermatitis
- Diabetic Neuropathy
- Rheumatoid Arthritis
- Dosing
- Evening Primrose Oil 500 mg capsules, 6 per day
- Adverse Effects
- Well tolerated
- Nausea
- Diarrhea
- Stool softening
- Headache
- May predispose to Seizure Disorder
- Efficacy
- Variable results in studies
- Small trials suggest unlikely benefit for most proposed indications
- Atopic Dermatitis
- Mastalgia
- Menopause
- Premenstrual Syndrome
- Insufficient evidence to support the use for other indications
- Diabetic Neuropathy
- Rheumatoid Arthritis
-
Drug Interactions: Possible interactions
- Phenothiazine Neuroleptics
- Anticonvulsants
- References
- Bayles (2009) Am Fam Physician 80(12): 1405-8 [PubMed]
- Chenoy (1994) BMJ 308(6927): 501-3 [PubMed]
- Pye (1985) Lancet 2:373-7 [PubMed]