Pharmacology Book



Aka: Chasteberry, Vitex agnus-castus, Monk's Pepper, Chaste Tree Berry
  1. History: Naming
    1. Used by European celibate clergy to decrease libido
  2. Mechanism
    1. Components: Flavinoids, glycosides, Essential Oils
    2. Key effects: Estrogen and Progesterone
      1. Low dose (example: 20 to 120 mg/day)
        1. May inhibit FSH release and decrease Estrogen level
        2. May stimulate LH release and increase Progesterone
      2. High dose (example: 480 mg/day)
        1. Stimulates Prolactin release
        2. Appears to not affect FSH, LH, Estrogen, Progestins
    3. Other effects
      1. Acts at central Dopamine receptors
  3. Clinical uses
    1. Uses where Chasteberry may be possibly effective
      1. Cyclical Mastalgia
      2. Premenstrual Syndrome
      3. May improve fertility (contraindicated in pregnancy)
    2. Uses where there is insufficient evidence
      1. Altering libido
      2. Stimulation of Lactation
  4. Pregnancy and Lactation
    1. Contraindicated in pregnancy
    2. Not recommended in Lactation
  5. Drug Interactions
    1. None reported
    2. May affect Dopaminergic medications
      1. Medications for Parkinsonism
      2. Metoclopramide
  6. Dosing
    1. Fruit extract 20 to 40 mg daily
  7. Adverse Effects
    1. Gastrointestinal upset
    2. Headache, Dizziness or Fatigue
    3. Xerostomia
  8. References
    1. Roemheld-Hamm (2005) Am Fam Physician 72(5):821-4 [PubMed]
    2. Schellenberg (2001) BMJ 322:134-7 [PubMed]

You are currently viewing the original '\legacy' version of this website. Internet Explorer 8.0 and older will automatically be redirected to this legacy version.

If you are using a modern web browser, you may instead navigate to the newer desktop version of fpnotebook. Another, mobile version is also available which should function on both newer and older web browsers.

Please Contact Me as you run across problems with any of these versions on the website.

Navigation Tree