Pharmacology Book



Aka: Chondroitin, Chondroitin sulfate
  1. Indications
    1. Osteoarthritis (not recommended)
  2. Mechanism
    1. Endogenous glycosaminoglycan contained in joint matrix
  3. Efficacy: Does not appear effective for Osteoarthritis
    1. Effect requires at least one month of therapy
    2. Recent large studies suggest that Chondroitin is not effective
      1. Initially appeared more effective than Placebo at relieving pain
      2. Adding Chondroitin to Glucosamine does not offer significant benefit
    3. References
      1. Reichenbach (2007) Ann Intern Med 146:580-90 [PubMed]
  4. Source
    1. Animal sources such as shark and cow cartilage
      1. Theoretical risk of animal disease contamination
  5. Dosing
    1. Chondroitin 400 mg orally three time daily
  6. Adverse Effects
    1. Well tolerated
    2. Gastrointestinal upset
  7. References
    1. Leeb (2000) J Rheumatol 27:205-11 [PubMed]
    2. McAlindon (2000) JAMA 283:1469-75 [PubMed]

Chondroitin (C0008454)

Definition (CSP) family of acetylgalactosamine mucopolysaccharides.
Definition (MSH) A mucopolysaccharide constituent of chondrin. (Grant & Hackh's Chemical Dictionary, 5th ed)
Concepts Biologically Active Substance (T123) , Carbohydrate (T118) , Pharmacologic Substance (T121)
MSH D002807
LNC LP21381-6
English chondroitin, CHONDROITIN, Chondroitin, Chondroitin [Chemical/Ingredient], chondroitins
Swedish Kondroitin
Czech chondroitin
Finnish Kondroitiini
Polish Chondroityna
Portuguese Condroitim, Condroitina
French Chondroïtine
German Chondroitin
Italian Condroitina
Spanish Condroitin
Derived from the NIH UMLS (Unified Medical Language System)

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