Neurology Book

//fpnotebook.com/

Triptan Overdose

Aka: Triptan Overdose, Triptan Toxicity, Triptan Poisoning
  1. See Also
    1. Triptan
    2. Serotonin Syndrome
  2. Background
    1. Single doses as high as 400 mg in adults are well tolerated
    2. Overdose is usually not fatal, unless combined with other serotonergic drugs (Serotonin Syndrome)
  3. Signs
    1. Nausea, Vomiting or Diarrhea
    2. Chest Pain including coronary ischemia, Hypertension, Tachycardia or Dysrhythmia
    3. Somnolence, Dizziness, Vertigo or Paresthesias (rarely CVA)
    4. Diaphoresis
    5. Serotonin Syndrome (Agitation, autonomic hyperactivity, Tremor, Clonus)
  4. Evaluation
    1. See Unknown Ingestion including toxicologic evaluation
    2. Serum chemistry panel
    3. Electrocardiogram
  5. Approach
    1. See Serotonin Syndrome
    2. Activate charcoal if indicated (significant Overdose with early presentation within 1-2 hours)
    3. Agitation
      1. Benzodiazepines
    4. Refractory symptomatic Hypertension
      1. Nicardipine or Clevidipine
      2. Labetalol
      3. Nitroprusside
      4. Phentolamine
    5. Coronary Ischemia
      1. Nitroglycerin
    6. Dysrhythmia
      1. Amiodarone or Lidocaine
    7. Disposition
      1. May discharge home if asymptomatic at 6 hours after ingestion
      2. Observe and treat symptomatic ingestions
  6. References
    1. Tomaszewski (2022) Crit Dec Emerg Med 36(8): 32

You are currently viewing the original 'fpnotebook.com\legacy' version of this website. Internet Explorer 8.0 and older will automatically be redirected to this legacy version.

If you are using a modern web browser, you may instead navigate to the newer desktop version of fpnotebook. Another, mobile version is also available which should function on both newer and older web browsers.

Please Contact Me as you run across problems with any of these versions on the website.

Navigation Tree