Rivastigmine

Aka: Rivastigmine, Exelon

1. See Also
   1. Acetylcholinesterase Inhibitor
   2. Dementia
   3. Dementia Management
   4. Donepezil (Aricept)
   5. Galantamine (Reminyl)
2. Indications
   1. Alzheimer Disease
   2. Lewy Body Dementia
3. Mechanism
   1. See Acetylcholinesterase Inhibitor
   2. Carbamate-based noncompetitive Cholinesterase Inhibitor
   3. Inhibits butyrylcholinesterase and acetylcholinesterase
   4. Increases Cholinergic transmission
4. Pharmacokinetics: Oral Route
   1. Peak: 1 hour
   2. Duration: 10 hours
5. Drug Interactions
   1. No significant Drug Interactions
6. Efficacy
   1. Modestly improves scores on neuropsychological tests
   2. Benefits decrease after 40 weeks of treatment
7. Adverse Effects
   1. See Acetylcholinesterase Inhibitor
   2. Specific adverse effects reported for Rivastigmine, not seen with other Acetylcholinesterase Inhibitors
      1. Abdominal Pain
      2. Atrial Fibrillation
      3. Myocardial Infarction
8. Dosing
   1. Oral Route
      1. Initial: 1.5 mg orally twice daily with food for at least 2 weeks (4 weeks for Lewy Body Dementia)
      2. Next: 3 mg orally twice daily with food for at least 2 weeks (4 weeks for Lewy Body Dementia)
      3. Next: 4.5 mg orally twice daily with food for at least 2 weeks (4 weeks for Lewy Body Dementia)
      4. Next: 6 mg orally twice daily with food
   2. Transdermal Patch
      1. Initial: 4.6 mg patch every 24 hours for at least 4 weeks
      2. Next: 9.5 mg patch every 24 hours for at least 4 weeks
      3. Next: 13.3 mg patch every 24 hours
9. References
   1. (2000) Med Lett Drugs Ther 42(1089):93-4 [PubMed]
   2. Corey-Bloom (1998) Int J Geriatr Psychopharm 1:55 [PubMed]
   3. Epperly (2017) Am Fam Physician 95(12): 771-8 [PubMed]
   4. Rosler (1999) BMJ 318:633 [PubMed]