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Perampanel
Aka: Perampanel, Fycompa
- Indications
- Refractory partial-onset Seizures
- Mechanism
- Antiepileptic
- Glutamate receptor antagonist (first in the class)
- Selective for AMPA receptors
- Precautions
- FDA Schedule III
- Abuse potential due to associated euphoria
- Adverse Effects
- Mood changes
- Euphoria
- Anger
- Hostility
- Dizziness
- Sedation
- Dosing
- FDA approved for age over 12 years
- Initial: 2 mg orally at bedtime
- Titrate To: 4-8 mg orally at bedtime (increase by 2 mg/day on a weekly basis)
- Maximum: 12 mg/day
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Drug Interactions
- Levonorgestrel containing contraceptives
- Perampanel decreases the contraceptive efficacy
- Use alternative agents
- Resources
- Medscape
- http://reference.medscape.com/drug/fycompa-perampanel-999784
- References
- (2014) Presc Lett 21(11): 65
- French (2012) Neurology 79(6):589-96 [PubMed]