Neurology Book

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Perampanel

Aka: Perampanel, Fycompa
  1. Indications
    1. Refractory partial-onset Seizures
  2. Mechanism
    1. Antiepileptic
    2. Glutamate receptor antagonist (first in the class)
      1. Selective for AMPA receptors
  3. Precautions
    1. FDA Schedule III
      1. Abuse potential due to associated euphoria
  4. Adverse Effects
    1. Mood changes
      1. Euphoria
      2. Anger
      3. Hostility
    2. Dizziness
    3. Sedation
  5. Dosing
    1. FDA approved for age over 12 years
    2. Initial: 2 mg orally at bedtime
    3. Titrate To: 4-8 mg orally at bedtime (increase by 2 mg/day on a weekly basis)
    4. Maximum: 12 mg/day
  6. Drug Interactions
    1. Levonorgestrel containing contraceptives
      1. Perampanel decreases the contraceptive efficacy
      2. Use alternative agents
  7. Resources
    1. Medscape
      1. http://reference.medscape.com/drug/fycompa-perampanel-999784
  8. References
    1. (2014) Presc Lett 21(11): 65
    2. French (2012) Neurology 79(6):589-96 [PubMed]
Medication Costs
fycompa (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
FYCOMPA 2 MG TABLET $11.92 each
FYCOMPA 4 MG TABLET $24.19 each
FYCOMPA 6 MG TABLET $24.11 each
FYCOMPA 8 MG TABLET $23.84 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

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