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Methysergide
Aka: Methysergide, Sansert- Indications
- Second line drug for Migraine Prophylaxis
- Use only with Neurology Consultation (due to toxicity)
- Mechanism
- Serotonin Antagonist (partial agonist activity)
- Dosing
- Sansert 4-8 mg PO qd
- Drug holiday for 4 weeks every 6 months
- Adverse Effects
- Retroperitoneal fibrosis
- Weight gain
- Edema
Methysergide (C0025842) |
|
|---|---|
| Definition (MSH) | An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D008784 |
| SnomedCT | 363566005, 11796006, 387044000 |
| English | Dimethylergometrin, Methylmethylergonovine, Methysergide, Ergoline-8-carboxamide, 9,10-didehydro-N-(1-(hydroxymethyl)propyl)-1,6-dimethyl-, (8beta(S))-, Methysergide [Chemical/Ingredient], Methysergide product, Methysergide product (substance), methysergide, Methysergide (product), Methysergide (substance), methylsergide, METHYSERGIDE |
| Swedish | Metysergid |
| Czech | methysergid |
| Finnish | Metysergidi |
| Russian | DIMETILERGOMETRIN, METIZERGID, METILMETILERGONOVIN, ДИМЕТИЛЭРГОМЕТРИН, МЕТИЗЕРГИД, МЕТИЛМЕТИЛЭРГОНОВИН |
| Japanese | メチルメチルエルゴノビン, メチセルギド, デセリル, マレイン酸メチセルギド, メチセルギドマレイン酸塩, サンサート, ジメチルエルゴメトリン, マレイン酸水素メチセルギド |
| Portuguese | Metilmetilergonovin, Metisergida, Dimetilergometrina |
| Croatian | METIZERGID |
| Polish | Sansert, Deseril, Metysergid |
| Spanish | metisergida (producto), metisergida (sustancia), metisergida, Dimetilergometrina, Metilmetilergonovina, Metisergida |
| French | Méthysergide |
| German | Dimethylergometrin, Methylmethylergonovin, Methysergid |
| Italian | Metisergide |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Sansert (C0036177) |
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|---|---|
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D008784 |
| English | sansert, deseril, desril, Sansert, Deseril, Desril, Alliance Brand of Methysergide Maleate, Désernil Sandoz, Désernil-Sandoz, Novartis Brand of Methysergide Maleate |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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