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Intranasal Dihydroergotamine
Aka: Intranasal Dihydroergotamine, Migranal
- Indications
- Migraine Abortive Management
- Efficacy
- Significant Migraine response in 30 minutes
- Migranal: 70%
- Placebo: 28%
- Reference
- Gallagher (1996) Arch Neurol 53:1285-91 [PubMed]
- Dosing
- Prepare sprayer by inserting ampule and prime pump
- Use one spray each nostril
- May repeat x1 after 15 minutes (Total dose = 2mg)
- Maximum use is 2 times per week
- Advantages
- Lasts longer than intranasal Imitrex
- Rebound Headache less common than Imitrex
- Rebound HeadacheIncidence: 15% within 24 hours
- Less expensive than Intranasal Imitrex ($16/dose)
- Disadvantages
- Does not work as fast as intranasal Imitrex
- More complicated to use than intranasal Imitrex
- Adverse Effects
- Rhinitis
- Nausea
- Taste perversion