Neurology Book



Aka: Galantamine, Reminyl, Razadyne
  1. See Also
    1. Acetylcholinesterase Inhibitor
    2. Dementia
    3. Dementia Management
    4. Rivastigmine (Exelon)
    5. Donepezil (Aricept)
  2. Indication
    1. Alzheimer's Disease related Dementia
  3. Mechanism
    1. Acetylcholinesterase Inhibitor
    2. Acts also at nicotinic receptors
    3. Derived from Daffodil bulbs
  4. Pharmacokinetics
    1. Half-Life: 7 hours in elderly patients
    2. Metabolized by liver enzymes: CYP2D6 and CYP3A4
  5. Dosing
    1. May require concurrent Antiemetic use
    2. Immediate Release
      1. Start: 4 mg orally twice daily with breakfast and dinner for 4 weeks
      2. Maintenance: 8 mg orally twice daily for at least 4 weeks
      3. Consider increase to 12 mg orally twice daily if indicated
    3. Extended Release
      1. Start: 8 mg orally daily for 4 weeks
      2. Maintenance: 16 mg orally daily for at least 4 weeks
      3. Consider increase to 24 mg orally daily if indicated
  6. Adverse Effects
    1. See Acetylcholinesterase Inhibitor
    2. Bradycardia has also been reported with Galantamine
  7. Efficacy
    1. Moderately preserved cognitive function for >6 months
    2. References
      1. Raskind (2000) Neurology 54:2261 [PubMed]
      2. Tariot (2000) Neurology 54:2269 [PubMed]
  8. References
    1. (2001) Med Lett Drugs Ther 43(1107):53-4 [PubMed]
    2. Epperly (2017) Am Fam Physician 95(12): 771-8 [PubMed]
Medication Costs
galantamine (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
GALANTAMINE ER 16 MG CAPSULE Generic $1.69 each
GALANTAMINE ER 24 MG CAPSULE Generic $1.94 each
GALANTAMINE ER 8 MG CAPSULE Generic $1.59 each
GALANTAMINE HBR 12 MG TABLET Generic $0.82 each
GALANTAMINE HBR 4 MG TABLET Generic $1.21 each
GALANTAMINE HBR 8 MG TABLET Generic $1.04 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Galantamine (C0016967)

Definition (MSH) A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D005702
SnomedCT 323377002, 395727007
English Galantamin, Lycoremine, galanthamine, lycoremine, Galantamine [Chemical/Ingredient], galantamin, GALANTAMINE, galantamine, Galanthamine, 6H-Benzofuro(3a,3,2-ef)(2)benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, Galantamine, Galantamine (product), Galantamine (substance)
Swedish Galantamin
Czech galanthamin, galantamin
Finnish Galantamiini
Japanese リコレミン, ガランタミン, 臭化水素酸ガランタミン, ガランタミン臭化水素酸塩
Polish Niwalina, Galantamina
Spanish galantamina (producto), galantamina (sustancia), galantamina, Galantamina, Licorémina
French Galantamine, Galanthamine
German Galantamin, Galanthamin, Lycoremin
Italian Galantamina
Portuguese Galantamina, Licoremina
Derived from the NIH UMLS (Unified Medical Language System)

Razadyne (C0939465)

Definition (MSH) Name of the FDA approved preparation from J&J.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D005702
Czech reminyl
German Reminyl
English Razadyne, Ortho McNeil Neurologics Brand of Galantamine, Ortho-McNeil Neurologics Brand of Galantamine, reminyl, Reminyl
Portuguese Reminyl
Spanish Reminilo
Derived from the NIH UMLS (Unified Medical Language System)

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