Neurology Book

//fpnotebook.com/

Ditan

Aka: Ditan, Lasmiditan, Reyvow
  1. Indications
    1. Acute Migraine Headache
      1. Third-line agent in acute Migraine Headaches refractory to NSAIDS and Triptans
  2. Mechanism
    1. Selective Serotonin5-HT1F Agonist
      1. Differs from Triptan binding sites
  3. Preparations
    1. Reyvow (Lasmiditan)
      1. Costs $85 per tablet (contrast with 70 cents per Sumatriptan tablet)
      2. Limit to 4 doses per month
  4. Dosing
    1. Single dose, and no benefit from re-dosing <24 hours
    2. Available as 50, 100 and 200 mg doses
  5. Efficacy
    1. NNT 10 for one patient to be pain free at 2 hours
      1. Contrast with NNT 5 for Sumatriptan
      2. Although 50% are pain at 2 hours, 43% are pain free at 2 hours after Placebo
  6. Adverse Effects
    1. Does NOT cause vasospasm (in contrast to Triptans)
    2. Transient minor increases in Blood Pressure (2-3 mmHg) and decreased Heart Rate (5-10 bpm) after 200 mg dose
    3. Euphoria and Hallucinations
      1. Do not drive for 8 hours after dose
      2. Schedule V agent
    4. Serotonin Syndrome
    5. Other more common side effects
      1. Dizziness
      2. Fatigue
      3. Paresthesias
      4. Sedation
      5. Nausea and Vomiting
      6. Muscle Weakness
  7. References
    1. (2020) Presc Lett 27(3): 13
    2. Bowman (2020) Crit Dec Emerg Med 34(11):28

You are currently viewing the original 'fpnotebook.com\legacy' version of this website. Internet Explorer 8.0 and older will automatically be redirected to this legacy version.

If you are using a modern web browser, you may instead navigate to the newer desktop version of fpnotebook. Another, mobile version is also available which should function on both newer and older web browsers.

Please Contact Me as you run across problems with any of these versions on the website.

Navigation Tree