Neurology Book

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Calcitonin Gene-Related Peptide Blocker

Aka: Calcitonin Gene-Related Peptide Blocker, CGRP Antagonist, Aimovig, Erenumab
  1. Indications
    1. Migraine Prophylaxis if refractory to first-line agents
  2. Mechanism
    1. CalcitoninGene-Related Peptide (CGRP) levels increases at Migraine Headache onset
      1. Vasodilator
      2. Pain sensitizer
    2. CGRP Antagonists block CGRP activity
  3. Preparation: Erenumab (Aimovig)
    1. Dosing
      1. Inject SQ once monthly in Abdomen, thigh, upper arm
  4. Adverse Effects
    1. Injection site mild reactions
  5. Disadvantages
    1. Limited safety data outside healthy patients without comorbidity at time of 2018 release
    2. Expensive: $6900 per year
  6. References
    1. (2018) Presc Lett 25(8)

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