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Calcitonin Gene-Related Peptide Blocker
Aka: Calcitonin Gene-Related Peptide Blocker, CGRP Antagonist, Erenumab, Ajovy, Fremanezumab, Emgality, Galcanezumab, Aimovig
- See Also
- Gepant
- Migraine Prophylaxis
- Indications
- Migraine Prophylaxis if refractory to first-line agents
- Mechanism
- CGRP Antagonists block CGRP activity (vasodilator)
- CalcitoninGene-Related Peptide (CGRP) levels increases at Migraine Headache onset
- Vasodilator
- Pain sensitizer
- Preparations
- Erenumab (Aimovig) autoinjector
- Inject SQ once monthly in Abdomen, thigh, upper arm
- Ajovy (Fremanezumab)
- Three injections from prefilled syringes once every 3 months
- Emgality (Galcanezumab)
- Once monthly injection via pen
- Adverse Effects
- Injection site mild reactions
- Efficacy
- Reduces migraine Incidence by 2 fewer Migraine days/month
- Disadvantages
- Limited safety data outside healthy patients without comorbidity at time of 2018 release
- Expensive: $6900 per year
- References
- (2018) Presc Lett 25(8)
- (2018) Presc Lett 25(12): 70