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Cognex
Aka: Cognex, Tacrine
- See Also
- Alzheimer's Disease
- Rivastigmine (Exelon)
- Donepezil (Aricept)
- Galantamine (Reminyl)
- Background
- Replaced by newer agents (e.g. Aricept) - avoid use due to hepatotoxicity risk
- Indications
- No longer used in U.S. due to hepatotoxicity risk
- Mild to Moderate Dementia (Folstein MMSE: 10-26)
- Mechanism
- First Acetylcholinesterase Inhibitor
- Other agents are now preferred
- Efficacy
- Response in 20% of patients
- Aricept offers similar efficacy and less toxicity
- Dosing
- Start at 10 mg PO qid for 4 weeks
- Increase to 20 mg PO qid for 4 weeks
- Titrate to maximum of 40 mg
- Adverse effects
- Hepatotoxicity
- Follow Liver Function Tests (esp. SGPT) every 2 weeks