Neurology Book

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CSF Latex Agglutination

Aka: CSF Latex Agglutination, CSF Antigens
  1. See Also
    1. Cerebrospinal Fluid
    2. Lumbar Puncture
  2. Indications
    1. Rarely used now (See CSF PCR which is preferred)
    2. Suspected Bacterial Meningitis with negative tests
  3. Advantages
    1. Results available in 20 minutes
  4. Efficacy
    1. Test Specificity: High
    2. Test Sensitivity: Low overall (does not rule-out Bacterial Meningitis)
      1. HaemophilusInfluenzae Type B: 60-100%
      2. Low sensitivity for Neisseria Meningitidis
      3. Low sensitivity in most other Bacterial Meningitis
  5. Preparations: Antigens tested
    1. HaemophilusInfluenzae type B
    2. Streptococcus Pneumoniae
    3. Escherichia coli K1
    4. Neisseria Meningitidis Groups A, B, C, Y
    5. Group B Streptococcus
    6. Streptococcus agalactiae
  6. References
    1. Kooiker in Roberts (1998) Procedures in ER, p. 1067-75
    2. Ravel (1995) Lab Medicine, Mosby, p. 294-9
    3. Tunkel in Mandell (2000) Infectious Disease, p. 974-8
    4. Seehusen (2003) Am Fam Physician 68:1103-8 [PubMed]

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