Pulmonology Book


Reactive Airway Dysfunction Syndrome

Aka: Reactive Airway Dysfunction Syndrome, Irritant-induced Asthma
        1. Reactive Airway Dysfunction Syndrome
  1. Pathophysiology
    1. Type of Work-Related Asthma
      1. Irritant-induced Asthma accounts for 10% of Occupational Asthma cases
      2. Allergic Occupational Asthma (sensitizer IgE mediated immune response) accounts for 90% of cases
    2. Irritants cause direct cell damage and inflammation
      1. Typically caused by a single, high exposure to an irritant
  2. Symptoms
    1. Asthma symptoms occur within 24 hours of exposure
  3. Causes
    1. 2-DiethylAminoEthanolamine
    2. Acetic Acid
    3. Anhydrous ammonia
    4. Bleaching chemicals
    5. Burning paint fumes
    6. Chlorine gas (e.g. paper mill worker)
    7. Diesel exhaust fumes
    8. Free-based Cocaine
    9. Floor sealant
    10. Hydrochloric acid
    11. Hydrogen sulfide
    12. Inhaled smoke fumes (e.g. firefighters, rescue workers)
    13. Irritant dust (e.g. construction worker, rescue worker)
    14. Phosgene
    15. Phosphoric acid
    16. Silicon
    17. Silo gas
    18. Sodium hydroxide
    19. Sulfuric acid
    20. Tear Gas
    21. Toluene diisocyanate
    22. Trichlorosilane
    23. Welding fumes
    24. Zinc chloride
  4. References
    1. Brooks in Rom (1998) Environmental Medicine, p. 481-524
    2. Bebko (2016) Am Fam Physician 93(12): 1000-6 [PubMed]
    3. Youakim (2001) Am Fam Physician 64(11):1839-48 [PubMed]

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