Pulmonology Book


Parapneumonic Effusion

Aka: Parapneumonic Effusion, Pleural Empyema, Lung Empyema, Thoracic Empyema
  1. See Also
    1. Pleural Effusion
    2. Pleural Effusion Causes
  2. Definitions
    1. Parapneumonic Effusion
      1. Infectious cause of Pleural Effusion (e.g. Pneumonia, Lung Abscess)
    2. Pleural Empyema
      1. Parapneumonic Effusion complicated by pustular collection
  3. Causes: Parapneumonic Effusion
    1. Bacterial Pneumonia
    2. Mycobacterium tuberculosis
    3. Fungal Lung Infection
    4. Viral Pneumonia
    5. Parasitic Infection of Lung
  4. Causes: Empyema (pus collection, Bronchopleural Fistula)
    1. See Empyema Pleural Effusion Findings
    2. Infection
      1. Pneumonia (50% of empyema causes)
        1. Community Acquired Empyema
          1. Pneumococcus
          2. Streptococcus species
        2. Health-Care Associated Empyema
          1. Staphylococcus
          2. Enterococcus
          3. Enterobacteriaceae
      2. Abscess
        1. Lung Abscess
        2. Subphrenic abscess
      3. Mycobacterium tuberculosis
      4. Fungal infections
    3. Chest Trauma (especially penetrating chest wounds)
    4. Spontaneous Pneumothorax
  5. Differential Diagnosis
    1. See Pleural Effusion Causes
    2. Malignancy
    3. Tuberculosis
    4. Pulmonary Embolism
  6. Symptoms
    1. Persistent Fever
    2. Malaise
    3. Failure to improve despite days of antibiotics
    4. Pleuritic Chest Pain (distinguish from Pulmonary Embolism)
    5. Findings with chronic Parapneumonic Effusion (distinguish from malignancy, Tuberculosis)
      1. Weight Loss
      2. Night Sweats
      3. Anorexia
  7. Labs
    1. See Pleural Fluid
    2. Pleural cell count with differential
    3. Pleural Gram Stain and culture
      1. Cultures identify organism in 70% of empyema, but only 22% of other complicated Parapneumonic Effusions
      2. Obtain Blood Cultures at same time to increase overall sensitivity
      3. Culture does not identify Tuberculosis
  8. Types
    1. Simple Parapneumonic Effusion (treated with antibiotics alone)
      1. Small volume, sterile exudative effusion
      2. No loculated fluid collections
      3. Negative Gram Stain and negative fluid cultures
      4. Pleural Fluid pH > 7.2
      5. Pleural Glucose normal
      6. Pleural Lactate Dehydrogenase (LDH) < 3 fold upper limit of normal
    2. Complicated Parapneumonic Effusion
      1. Loculated fluid collections develop
      2. Fluid is no longer sterile (distinguishes from simple Parapneumonic Effusion)
        1. Positive Gram Stain
        2. Positive Pleural Fluid culture
    3. Lung Empyema
      1. Pustular Pleural Fluid distinguishes empyema from complicated Parapneumonic Effusion
      2. Pleural Fluid pH <7.2
      3. Pleural fluid Gram Stain Positive
      4. Pleural FluidGlucose <60
  9. Course
    1. Phase 1: Exudative Parapneumonic Effusion
      1. Visceral pleura is permeable, allowing sterile exudate to form
      2. See Simple Parapneumonic Effusion as above
    2. Phase 2: Fibrinopurulent Parapneumonic Effusion
      1. Fibrin deposition on pleural surface
      2. Loculations form (visible on Lung Ultrasound or CT Chest)
      3. Infected, exudative fluid
      4. Progression to Lung Empyema when pustular fluid accumulates
    3. Phase 3: Organizing Parapneumonic Effusion
      1. Fibrous adhesions interfere with respiratory movement (Restrictive Lung Disease)
      2. Thoracic surgery may be required for decortication of adhesions
  10. Management: General
    1. Approach
      1. Antibiotics are indicated in all Parapneumonic Effusion
      2. Complicated Parapneumonic Effusions and Empyemas require drainage
    2. Simple Parapneumonic Effusion
      1. Consistent with Exudative Parapneumonic Effusion
      2. Treated as uncomplicated Parapneumonic Effusion with IV antibiotics
    3. Complicated Parapneumonic Effusion
      1. Consistent with Fibrinopurulent Parapneumonic Effusion
      2. IV Antibiotics are administered
      3. Catheter drainage required
      4. Intrapleural Fibrinolytics (see adjunctive measures below) are considered for loculation drainage
    4. Empyema
      1. IV antibiotics
      2. Chest Thoracostomy tube
  11. Management: Chest Tube
    1. Smaller Chest Tube catheters appear as effective as larger catheters
      1. However, catheter should be directed toward dependent regions of fluid collections and empyemas
    2. Tube Thoracostomy Indications in children
      1. Antibiotics alone for small effusions (<25% hemithorax, <1 cm depth on lateral decubitus xray) without Dyspnea
      2. Large effusion (>50% hemithorax)
      3. Respiratory Distress
    3. Tube Thoracostomy indications in adults
      1. Complicated Parapneumonic Effusion
      2. Empyema
    4. Adjunctive measures indicated for thick or loculated effusions
      1. Intrapleural Fibrinolysis (urokinase, Streptokinase, tPA)
      2. Deoxyribonuclease
      3. Video-assisted thoracoscopic surgery (refractory cases)
  12. References
    1. Natesan (2020) Crit Dec Emerg Med 34(7): 29-41

Empyema, Pleural (C0014013)

Definition (MSH) Suppurative inflammation of the pleural space.
Concepts Disease or Syndrome (T047)
MSH D016724
ICD10 J86, J86.9
SnomedCT 75952005, 196070008, 196058009, 196072000, 271502000, 69947005, 196069007, 155604003, 196074004, 271506002, 196071007, 196068004, 58554001, 405951008, 405950009
English Empyema, Pleural, Empyema, Thoracic, Empyemas, Pleural, Empyemas, Thoracic, Pleural Empyema, Pleural Empyemas, Pyothorax, Thoracic Empyema, Thoracic Empyemas, Lung empyema NOS, Pleural empyema, Thorax abscess NOS, Pulmonary Empyema, thoracic empyema, thoracic empyema (diagnosis), Pleural empyema NOS, Empyema, Pleural [Disease/Finding], empyema chest, empyema pleura, empyema pleural, lung empyema, pleural empyema, pulmonary empyema, empyema of lung, chest empyema, empyema of pleura (diagnosis), empyema of pleura, Pulmonary empyema, Empyema (& pleural) (disorder), Pleural empyema (disorder), Empyema NOS (& pleural) (disorder), Pleural empyema NOS (disorder), Purulent pleurisy (disorder), Thorax abscess NOS (disorder), Empyema (& pleural), Lung empyema NOS (disorder), Empyema NOS (& pleural), Abscess of thorax (diagnosis), Abscess of pleural cavity (diagnosis), thoracic abscess, thoracic abscess pleural cavity, Purulent pleurisy, Empyema of pleura (disorder), Empyema of pleura, Abscess of pleural cavity, Abscess of thorax, Abscess of thorax (disorder), Abscess of pleural cavity (disorder), pyothorax, chest; abscess, abscess; chest, abscess; thorax, pleurisy; purulent, pleurisy; suppurative, purulent; pleurisy, suppurative; pleurisy, thorax; abscess, Empyema of pleura, NOS, Suppurative pleurisy, Abscess, thorax, Empyema, chest, Empyema, lung, Empyema, pleura, Pleurisy, purulent, Pleurisy, suppurative
Swedish Varansamling i lungsäcken
Czech empyém hrudníku, empyém pleurální, Empyém plic, Hrudní empyém, pyotorax, pyothorax
Finnish Keuhkopussin märkäkertymä
Italian Piotorace, Empiema toracico, Empiema del polmone, Empiema pleurico
Korean 고름가슴
Polish Ropniak klatki piersiowej, Ropniak opłucnej
Japanese 胸腔蓄膿, 膿胸, ノウキョウ, 胸部蓄膿, 蓄膿-胸腔, 蓄膿-胸部
Spanish Piotorax, Empiema pulmonar, empiema pleural, empiema pleural, SAI, absceso torácico, SAI, pleuresía supurativa, pleuresía purulenta, empiema pulmonar, SAI, pleuresía purulenta (trastorno), empiema pleural (trastorno), empiema pulmonar, SAI (trastorno), absceso torácico, SAI (trastorno), empiema pleural, SAI (trastorno), empiema de la pleura (trastorno), empiema de la pleura, piotórax, absceso de tórax (trastorno), absceso de tórax, absceso de la cavidad pleural (trastorno), absceso de la cavidad pleural, Empiema Pleural, Empiema Torácico, Piotórax
Portuguese Empiema pulmonar, Empiema Pleural, Empiema Torácico, Piotórax
Dutch longempyeem, pyothorax, abces; borstkas, abces; thorax, borstkas; abces, pleuritis; purulent, pleuritis; suppuratief, purulent; pleuritis, suppuratief; pleuritis, thorax; abces, Empyeem, pleuraal, Empyeem, thorax-, Pleuraal empyeem, Pyothorax
French Empyème pulmonaire, Empyème pleural, Empyème thoracique, Pleurésie purulente, Pyothorax, Empyème de la plèvre, Empyème du thorax
German Lungenempyem, Empyem, Pleura-, Empyem, Thorax-, Pyothorax
Hungarian Pulmonalis empyema, pyothorax
Norwegian Empyema pleurae, Pyotoraks, Pleuraempyem
Derived from the NIH UMLS (Unified Medical Language System)

You are currently viewing the original 'fpnotebook.com\legacy' version of this website. Internet Explorer 8.0 and older will automatically be redirected to this legacy version.

If you are using a modern web browser, you may instead navigate to the newer desktop version of fpnotebook. Another, mobile version is also available which should function on both newer and older web browsers.

Please Contact Me as you run across problems with any of these versions on the website.

Navigation Tree