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Rifapentine
Aka: Rifapentine, Priftin
- See Also
- Rifampin
- Class
- Rifamycin
- Inhibits Bacterial RNA polymerase
- Mechanism
- Long-acting Rifampin derivative
- Contraindications
- Children under age 2 years
- Latent Tuberculosis with suspected resistance to Isoniazid or Rifampin
- HIV patients on Antiretrovirals (due to lower drug levels and risk of resistance)
- Unknown safety in pregnancy
- Dosing
- Tuberculosis
- Part of multi-drug regimen; high risk of drug resistance Tb if used alone
- Rifapentine 600 mg orally twice weekly for 2 months then once weekly for 4 months
- Latent Tuberculosis
- See Latent Tuberculosis
- Adverse Effects
- See Rifampin
- Hyperuricemia
- Body secretion discoloration (orange to brown)
- Discolors urine and Contact Lenses
- Hepatotoxicity (uncommon)
- Thrombocytopenia
- Neutropenia (rare)
-
Drug Interactions
- See Rifampin
- Metabolized by Cytochrome P-450 3A3/4
- Monitoring
- Baseline Liver Function Tests and clinical evaluations
- References
- (2011) MMWR Morb Mortal Wkly Rep 60(48): 1650-3 [PubMed]
- Hartman-Adams (2014) Am Fam Physician 89(11): 889-96 [PubMed]