Pulmonology Book



Aka: Ethambutol
  1. Background
    1. Drug resistance emerges rapidly
      1. Must be used with other antituberculous drugs
  2. Indications
    1. Active Tuberculosis
  3. Dosing
    1. Adult: 15-25 mg/kg PO
    2. Pediatric: 15-25mg/kg PO
  4. Adverse Effects
    1. Decreased Visual Acuity
    2. Retrobulbar Optic Neuritis
    3. Peripheral Neuropathy
    4. Rash
  5. Monitoring
    1. Baseline
      1. Serum Creatinine
        1. Renal Dosing may be needed due to primarily Renal Clearance
      2. Visual acquity
      3. Color Perception
    2. Monthly retesting
      1. Visual acquity
      2. Color Perception
Medication Costs
ethambutol (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
ETHAMBUTOL HCL 400 MG TABLET Generic $0.83 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Ethambutol (C0014964)

Definition (NCI) An antibiotic with bacteriostatic, antimicrobial and antitubercular properties. Ethambutol interferes with the biosynthesis of arabinogalactan, a major polysaccharide of the mycobacterial cell wall. It inhibits the polymerization of cell wall arabinan of arabinogalactan and lipoarabinomannan by blocking arabinosyl transferases and induces the accumulation of D-arabinofuranosyl-P-decaprenol, an intermediate in arabinan biosynthesis. This results in halting bacterial growth.
Definition (MSH) An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)
Definition (CSP) antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus; it may also inhibit the synthesis of spermidine in mycobacteria.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D004977
SnomedCT 24450004, 387129004
LNC LP15625-4, MTHU008452
English Ethambutol, ethambutol, 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (S-(R*,R*))-, Ethambutol [Chemical/Ingredient], ETHAMBUTOL, Ethambutolol, Ethambutol (product), Ethambutol (substance)
Swedish Etambutol
Czech ethambutol
Finnish Etambutoli
Japanese 塩酸エタンブトール, エタンブトール
Polish Etambutol
Spanish etambutol (producto), etambutol (sustancia), etambutol, Etambutol
French Éthambutol
German Ethambutol
Italian Etambutolo
Portuguese Etambutol
Derived from the NIH UMLS (Unified Medical Language System)

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