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Ethambutol
Aka: Ethambutol- Background
- Drug resistance emerges rapidly
- Must be used with other antituberculous drugs
- Drug resistance emerges rapidly
- Indications
- Multi-drug Tuberculosis Treatment regimen
- Dosing
- Adult: 15-25 mg/kg PO
- Pediatric: 15-25mg/kg PO
- Adverse Effects
- Monitoring
- Baseline
- Serum Creatinine
- Visual acquity
- Color Perception
- Periodic re-testing
- Visual acquity
- Color Perception
- Baseline
| Medication Costs | ||
|---|---|---|
| ethambutol (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
| ETHAMBUTOL HCL 400 MG TABLET | Generic | $0.83 each |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Ethambutol (C0014964) |
|
|---|---|
| Definition (NCI) | An antibiotic with bacteriostatic, antimicrobial and antitubercular properties. Ethambutol interferes with the biosynthesis of arabinogalactan, a major polysaccharide of the mycobacterial cell wall. It inhibits the polymerization of cell wall arabinan of arabinogalactan and lipoarabinomannan by blocking arabinosyl transferases and induces the accumulation of D-arabinofuranosyl-P-decaprenol, an intermediate in arabinan biosynthesis. This results in halting bacterial growth. |
| Definition (MSH) | An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863) |
| Definition (CSP) | antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus; it may also inhibit the synthesis of spermidine in mycobacteria. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D004977 |
| SnomedCT | 24450004, 387129004 |
| LNC | LP15625-4, MTHU008452 |
| English | Ethambutol, ethambutol, 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (S-(R*,R*))-, Ethambutol [Chemical/Ingredient], ETHAMBUTOL, Ethambutolol, Ethambutol (product), Ethambutol (substance) |
| Swedish | Etambutol |
| Czech | ethambutol |
| Finnish | Etambutoli |
| Russian | ETAMBUTOL, ЭТАМБУТОЛ |
| Japanese | 塩酸エタンブトール, エタンブトール |
| Polish | Etambutol |
| Spanish | etambutol (producto), etambutol (sustancia), etambutol, Etambutol |
| French | Éthambutol |
| German | Ethambutol |
| Italian | Etambutolo |
| Portuguese | Etambutol |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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